ArticleObesity (Silver Spring, Md.)2007
The SH2B gene is associated with serum leptin and body fat in normal female twins.
Article in Obesity (Silver Spring, Md.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Implication of European-derived adiposity loci in African Americans.International journal of obesity (2005) · 2012Pooled it
- Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers.Journal of obesity & metabolic syndrome · 2024Article
- SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Association of theNutrients · 2020Article
- Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.Experimental gerontology · 2018Article
- Biochemical and cellular properties of insulin receptor signalling.Nature reviews. Molecular cell biology · 2018Review
- The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.American journal of human genetics · 2017Article
- Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes.Molecular psychiatry · 2017Article
- Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.Genome medicine · 2015Article
- Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women.Saudi journal of biological sciences · 2014Article
- Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.Endocrinology · 2014Article
- SH2B1 regulation of energy balance, body weight, and glucose metabolism.World journal of diabetes · 2014Review
- Brain regulation of energy balance and body weight.Reviews in endocrine & metabolic disorders · 2013Review
- Leptin signaling and leptin resistance.Frontiers of medicine · 2013Review
- Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.BMC medical genomics · 2012Article
- The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.Atherosclerosis · 2011Article
- Parallel adaptive divergence among geographically diverse human populations.PLoS genetics · 2011Article
- Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children.Obesity facts · 2011Article
- Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population.Obesity facts · 2011Article
- The genetics of obesity.Current diabetes reports · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Src-homology-2 (SH2)-B, a Janus tyrosine kinase 2-interacting protein, has been identified recently as a key regulator of leptin and insulin sensitivity, glucose homeostasis, and body weight in mice. The aim of this study was to determine whether single-nucleotide polymorphisms (SNPs) in the human SH2B gene are associated with these variables. A tagging SNP (tSNP), Ala484Thr (rs7498665), was selected to represent five common SNPs (minor allele frequency > 0.05) in perfect linkage disequilibrium in a 16-kb region encompassing the SH2B gene. The tSNP was genotyped in 2455 white female twins (mean age, 47.4 +/- 12.6 years) from the St. Thomas' United Kingdom Adult Twin Registry (Twins United Kingdom). Ala484Thr (minor allele frequency, 0.38) was associated with serum leptin, total fat, waist circumference, and body weight (P = 0.02 to 0.04). The coding SNP has no predicted effect on protein structure or function and is likely to be in linkage disequilibrium with an as-yet unidentified functional variant in the SH2B gene. Our results support a role for SH2-B in modulating the regulation of body weight and fat by leptin in this female population. If SH2-B signaling is attenuated in diet-induced obesity, it could become a target for drug-induced leptin sensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.