ArticlePLoS medicine2007
Early-life family structure and microbially induced cancer risk.
Article in PLoS medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Gastric cancer burden and regional disparities among Helicobacter pylori-positive patients in the Americas: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Antibody-based detection tests for the diagnosis of Helicobacter pylori infection in children: a meta-analysis.PloS one · 2008Pooled it
- Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome.The Journal of infectious diseases · 2024Review
- The global, regional, and national burden of stomach cancer among adolescents and young adults in 204 countries and territories, 1990-2019: A population-based study.Frontiers in public health · 2023Article
- The Contribution of Avoidable Mortality to the Life Expectancy Gains in Korea between 1998 and 2017.International journal of environmental research and public health · 2020Article
- Prognosis of Young Survivors of Gastric Cancer in China and the U.S.: Determining Long-Term Outcomes Based on Conditional Survival.The oncologist · 2019Article
- Greater family size is associated with less cancer risk: an ecological analysis of 178 countries.BMC cancer · 2018Article
- Article
- Identifying strains that contribute to complex diseases through the study of microbial inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Regional inequalities in under-5 mortality in Nigeria: a population-based analysis of individual- and community-level determinants.Population health metrics · 2011Article
- Helicobacter pylori and gastric cancer in the Middle East: a new enigma?World journal of gastroenterology · 2010Review
- Article
- Understanding the rapid increase in life expectancy in South Korea.American journal of public health · 2010Article
- Viral commensalism in humans?The Journal of infectious diseases · 2008Article
- Article
- Article
- Parental family structure, Helicobacter pylori, and gastric adenocarcinoma.PLoS medicine · 2007Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCancer may follow exposure to an environmental agent after many decades. The bacterium Helicobacter pylori, known to be acquired early in life, increases risk for gastric adenocarcinoma, but other factors are also important. In this study, we considered whether early-life family structure affects the risk of later developing gastric cancer among H. pylori+ men. METHODS AND
findingsWe examined a long-term cohort of Japanese-American men followed for 28 y, and performed a nested case-control study among those carrying H. pylori or the subset carrying the most virulent cagA+ H. pylori strains to address whether family structure predicted cancer development. We found that among the men who were H. pylori+ and/or cagA+ (it is possible to be cagA+ and H. pylori- if the H. pylori test is falsely negative), belonging to a large sibship or higher birth order was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. For those with cagA+ strains, the risk of developing gastric cancer was more than twice as high (odds ratio 2.2; 95% confidence interval 1.2-4.0) among those in a sibship of seven or more individuals than in a sibship of between one and three persons.
conclusionsThese results provide evidence that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later, and these findings lead to new models to explain these interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.