ArticleWorld journal of gastroenterology2007
Ginkgo biloba extract (EGb 761) attenuates lung injury induced by intestinal ischemia/reperfusion in rats: roles of oxidative stress and nitric oxide.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Ginkgo biloba extract for prevention of acute mountain sickness: a systematic review and meta-analysis of randomised controlled trials.BMJ open · 2018Pooled it
- Intestinal Ischemia/Reperfusion Injury: Mechanisms, Diagnosis, and Therapeutic Advances.International journal of biological sciences · 2026Review
- Ac2-26 reduced the liver injury after cardiopulmonary bypass in rats via AKT1/GSK3β/eNOS pathway.Journal of cardiothoracic surgery · 2024Article
- Ac2-26 activated the AKT1/GSK3β pathway to reduce cerebral neurons pyroptosis and improve cerebral function in rats after cardiopulmonary bypass.BMC cardiovascular disorders · 2024Article
- Annexin A1 peptide Ac2-26 mitigates ventilator-induced lung injury in acute respiratory distress syndrome rats and partly depended on the endothelial nitric oxide synthase pathway.Acta cirurgica brasileira · 2023Article
- Alleviation of chemotherapy-induced acute lung injury via NLRP3/ ASC/ Caspase-1 signaling pathway.Toxicology research · 2022Article
- The Restoring Effect of Human Umbilical Cord-Derived Mesenchymal Cell-Conditioned Medium (hMSC-CM) against Carbon Tetrachloride-Induced Pulmonary Fibrosis in Male Wistar Rats.International journal of inflammation · 2022Article
- Ac2-26 mitigated acute respiratory distress syndrome rats via formyl peptide receptor pathway.Annals of medicine · 2021Article
- The α2AR/Caveolin-1/p38MAPK/NF-κB axis explains dexmedetomidine protection against lung injury following intestinal ischaemia-reperfusion.Journal of cellular and molecular medicine · 2021Article
- Diannexin Can Ameliorate Acute Respiratory Distress Syndrome in Rats by Promoting Heme Oxygenase-1 Expression.Mediators of inflammation · 2021Article
- Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats.Protoplasma · 2017Article
- The protective effect of infliximab against carbon tetrachloride-induced acute lung injury.Iranian journal of basic medical sciences · 2016Article
- Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway.American journal of translational research · 2016Article
- Mesenteric lymph duct drainage attenuates acute lung injury in rats with severe intraperitoneal infection.Inflammation · 2015Article
- Amelioration of meconium-induced acute lung injury by parecoxib in a rabbit model.International journal of clinical and experimental medicine · 2015Article
- Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats.International journal of clinical and experimental medicine · 2014Article
- NAC is associated with additional alleviation of lung injury induced by invasive pulmonary aspergillosis in a neutropenic model.Acta pharmacologica Sinica · 2009Article
- Immediate postconditioning during reperfusion attenuates intestinal injury.Intensive care medicine · 2009Article
- Carbon liberated from CO-releasing molecules attenuates leukocyte infiltration in the small intestine of thermally injured mice.World journal of gastroenterology · 2007Article
- Natural plant products in treatment of pulmonary arterial hypertension.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of ginkgo biloba extract (EGb 761) on lung injury induced by intestinal ischemia/reperfusion (II/R).
methodsThe rat model of II/R injury was produced by clamping the superior mesenteric artery for 60 min followed by reperfusion for 180 min. The rats were randomly allocated into sham, II/R, and EGb + II/R groups. In EGb + II/R group, EGb 761 (100 mg/kg per day) was given via a gastric tube for 7 consecutive days prior to surgery. Rats in II/R and sham groups were treated with equal volumes of the vehicle of EGb 761. Lung injury was assessed by light microscopy, wet-to-dry lung weight ratio (W/D) and pulmonary permeability index (PPI). The levels of malondialdehyde (MDA) and nitrite/nitrate (NO2(-)/NO3(-)), as well as the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) were examined. Western blot was used to determine the expression of inducible nitric oxide synthase (iNOS).
resultsEGb 761 markedly improved mean arterial pressure and attenuated lung injury, manifested by the improvement of histological changes and significant decreases of pulmonary W/D and PPI (P < 0.05 or 0.01). Moreover, EGb 761 markedly increased SOD activity, reduced MDA levels and MPO activity, and suppressed NO generation accompanied by down-regulation of iNOS expression (P < 0.05 or 0.01).
conclusionThe results indicate that EGb 761 has a protective effect on lung injury induced by II/R, which may be related to its antioxidant property and suppressions of neutrophil accumulation and iNOS-induced NO generation. EGb 761 seems to be an effective therapeutic agent for critically ill patients with respiratory failure related to II/R.
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