ReviewWorld journal of gastroenterology2007
Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.
Review in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes.Obesity (Silver Spring, Md.) · 2021Trial
- Serum pancreatitis-associated protein 1 concentrations in dogs with acute signs of gastrointestinal disease and normal or abnormal DGGR lipase activity.Journal of veterinary internal medicine · 2026Article
- STATs Signaling Pathways in Acute Pancreatitis: Mechanisms and Regulation.International journal of medical sciences · 2026Review
- Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation.Chinese journal of integrative medicine · 2024Article
- Observational
- Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis.Frontiers in genetics · 2021Article
- HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice.Journal of cellular and molecular medicine · 2020Article
- PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker.Cellular and molecular life sciences : CMLS · 2017Article
- REG3β modifies cell tumor function by impairing extracellular vesicle uptake.Scientific reports · 2017Article
- New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.PloS one · 2016Article
- Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.Nature medicine · 2015Article
- Article
- The influence of sex, gestational age, birth weight, blood transfusion, and timing of the heel prick on the pancreatitis-associated protein concentration in newborn screening for cystic fibrosis.Journal of inherited metabolic disease · 2013Article
- Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice.Diabetologia · 2012Article
- Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).Molecular and cellular biochemistry · 2012Article
- Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.Blood · 2011Article
- Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stroma.BMC genomics · 2011Article
- Article
- Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation.The Biochemical journal · 2009Article
- Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.Journal of vascular research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.