ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2007
Antihyperglycemic effects of Platycodon grandiflorum (Jacq.) A. DC. extract on streptozotocin-induced diabetic mice.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus.Animal models and experimental medicine · 2024Review
- Recent Advances of Natural Pentacyclic Triterpenoids as Bioactive Delivery System for Synergetic Biological Applications.Foods (Basel, Switzerland) · 2024Review
- Article
- Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of "Long-Covid".Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- Ameliorative Effects of Flavonoids fromNutrients · 2023Article
- Biotransformation of Platycosides, Saponins from Balloon Flower Root, into Bioactive Deglycosylated Platycosides.Antioxidants (Basel, Switzerland) · 2023Review
- Crude Saponin fromAntioxidants (Basel, Switzerland) · 2021Article
- Phenolic Constituents fromMolecules (Basel, Switzerland) · 2021Article
- Improved Bioactivity of 3-O-β-D-Glucopyranosyl Platycosides in BiotransformedJournal of microbiology and biotechnology · 2021Article
- The Pharmacological Effects and Health Benefits ofFoods (Basel, Switzerland) · 2020Review
- Article
- Antioxidant, inhibition of α-glucosidase and suppression of nitric oxide production in LPS-induced murine macrophages by different fractions of Actinidia arguta stem.Saudi journal of biological sciences · 2014Article
- Enhancement of chlorogenic acid production in hairy roots of Platycodon grandiflorum by over-expression of an Arabidopsis thaliana transcription factor AtPAP1.International journal of molecular sciences · 2014Article
- Antihyperglycemic, antihyperlipidemic and antiglycation effects of Byrsonima crassifolia fruit and seed in normal and streptozotocin-induced diabetic rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2010Article
- Platycoside N: a new oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum.Molecules (Basel, Switzerland) · 2010Article
- A prospective review of the health-promoting potential of Jing Si Herbal Tea.Tzu chi medical journalReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The root of Platycodon grandiflorum (Jacq.) A. DC has been reported to have a wide range of health benefits in oriental food. This study examined the hypoglycemic effects of Platycodon grandiflorum (Jacq.) A. DC aqueous-ethanol extract (PGE) in streptozotocin (STZ) -induced diabetic ICR mice (STZ diabetic mice) for the first time. The effects of PGE on blood glucose, plasma insulin levels and body weight were investigated. A significant decrease in blood glucose levels was observed after single administration of PGE. Furthermore, Glibenclamide and PGE significantly suppressed the rise in blood glucose after 30 min in the acute glucose tolerance test. Treatment with glibenclamide and PGE resulted in a reduction in blood glucose levels from the 2nd week, and this reduction was maintained until the 4th week of treatment. The body weight changed slightly in glibenclamide and PGE treated mice in comparison with the STZ control group. Plasma insulin levels were increased with glibenclamide treatment in STZ diabetic mice, whereas such effect was not observed with PGE. These results indicated that PGE could induce hypoglycemic effects without stimulating insulin secretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.