ArticleMolecular genetics and genomics : MGG2007
Characterization of regulatory non-catalytic hexokinases in Aspergillus nidulans.
Article in Molecular genetics and genomics : MGG, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Neofunctionalization of Glycolytic Enzymes: An Evolutionary Route to Plant Parasitism in the OomyceteMicroorganisms · 2022Article
- Article
- Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic YeastFrontiers in microbiology · 2019Article
- Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans.BMC genomics · 2018Article
- Carbon Catabolite Repression in Filamentous Fungi.International journal of molecular sciences · 2017Review
- The N-acetylglucosamine catabolic gene cluster in Trichoderma reesei is controlled by the Ndt80-like transcription factor RON1.Molecular microbiology · 2016Article
- Extreme Diversity in the Regulation of Ndt80-Like Transcription Factors in Fungi.G3 (Bethesda, Md.) · 2015Article
- VIB1, a link between glucose signaling and carbon catabolite repression, is essential for plant cell wall degradation by Neurospora crassa.PLoS genetics · 2014Article
- A p53-like transcription factor similar to Ndt80 controls the response to nutrient stress in the filamentous fungus, Aspergillus nidulans.F1000Research · 2013Article
- Two novel types of hexokinases in the moss Physcomitrella patens.BMC plant biology · 2011Article
- Meiotic regulators Ndt80 and ime2 have different roles in Saccharomyces and Neurospora.Genetics · 2010Article
- Aspergillus fumigatus catalytic glucokinase and hexokinase: expression analysis and importance for germination, growth, and conidiation.Eukaryotic cell · 2010Article
- Mutations in genes encoding sorting nexins alter production of intracellular and extracellular proteases in Aspergillus nidulans.Genetics · 2009Article
- Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth.Journal of experimental botany · 2009Article
- Article
- The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation.Current genetics · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hexokinases catalyse the first step in glucose metabolism and play a role in glucose sensing in mammals, plants and fungi. We describe a new class of hexokinases that appear to be solely regulatory in function. The Aspergillus nidulans hxkD gene (formerly named xprF) encodes a hexokinase-like protein. We constructed hxkDDelta gene disruption mutants which showed increased levels of extracellular protease in response to carbon starvation. The hxkDDelta mutations are not completely recessive, indicating that the level of the gene product is critical. Transcript levels of hxkD increase during carbon starvation and this response is not dependent on functional HxkD. A gene encoding a second atypical hexokinase (HxkC) was identified. The hxkCDelta gene disruption mutant exhibits a phenotype similar, but not identical, to hxkDDelta mutants. As with hxkD, mutations in hxkC are suppressed by loss-of-function mutations in xprG, which encodes a putative transcriptional activator involved in the response to nutrient limitation. We show that GFP-tagged HxkD was found only in nuclei suggesting a regulatory role for HxkD. GFP-tagged HxkC was associated with mitochondria. Homologs of hxkC and hxkD are conserved in multi-cellular fungi. Genes encoding atypical hexokinases are present in many genome sequence databases. Thus, non-catalytic hexokinases may be widespread.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.