ArticleJournal of neuro-oncology2007
Recurrences of meningiomas: predictive value of pathological features and hormonal and growth factors.
Article in Journal of neuro-oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Development of a Machine Learning Algorithm for the Prediction of WHO Grade 1 Meningioma Recurrence.Cureus · 2025Article
- MRI-based deep transfer learning models for predicting progesterone receptor expression in meningioma.Frontiers in oncology · 2025Article
- Single versus multiple reoperations for recurrent intracranial meningiomas.Journal of neuro-oncology · 2024Article
- Meningioma Prognostic Tool Based on Correlation of Histopathological Grading and Immunohistochemistry.Oman medical journal · 2024Article
- A prognostic model for tumor recurrence and progression after meningioma surgery: preselection for further molecular work-up.Frontiers in oncology · 2023Article
- High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma.Neurosurgical review · 2021Article
- Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications.Frontiers in oncology · 2021Article
- The relationship between vascular endothelial growth factor and histological grade in intracranial meningioma.Surgical neurology international · 2020Article
- Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions.Frontiers in oncology · 2020Article
- Histopathological Spectrum of Meningiomas with Emphasis on Prognostic Role of Ki67 Labelling Index.Iranian journal of pathology · 2020Article
- Recurrence/Regrowth in Grade I Meningioma: How to Predict?Frontiers in oncology · 2020Article
- Progesterone-only contraception is associated with a shorter progression-free survival in premenopausal women with WHO Grade I meningioma.Journal of neuro-oncology · 2018Article
- Article
- Are Osteopontin and Ki67 Expressions Different in Various Histologic Grades of Meningioma? An Iranian Experience.Iranian journal of pathology · 2015Article
- Bevacizumab therapy for adults with recurrent/progressive meningioma: a retrospective series.Journal of neuro-oncology · 2012Article
- Optic nerve sheath meningioma in the first decade of life: case report and review of the literature.Case reports in ophthalmology · 2012Article
- Stereotactic radiosurgery and radiotherapy for meningiomas: biomarker predictors of patient outcome and response to therapy.Journal of radiosurgery and SBRT · 2012Article
- The histopathological spectrum of human meningiomas.International journal of clinical and experimental pathology · 2012Article
- Usefulness of thallium-201 SPECT in the evaluation of tumor natures in intracranial meningiomas.Neuroradiology · 2011Article
- Pediatric meningioma: current approaches and future direction.Journal of neuro-oncology · 2011Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecurrence of apparently completely resected benign meningiomas is a rather frequent event, the mechanisms of which are still unclear. The aim of this study is to define the pathological features, proliferation indexes, growth factors and hormone receptor expression in predicting the meningioma recurrence.
methodsTwo groups of 50 completely resected benign WHO I meningiomas, with and without recurrence respectively, have been reviewed. Tumor location, consistency, vascularity, and histological types have been considered. Immunohistological studies include mitotic index (MI), Ki-67 LI, estrogen and progesterone receptors (ER and PR), Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor (EGF), and Bcl-2. All these factors have been correlated with the recurrence.
resultsThe tumor recurrence was not correlated with the patient age, tumor location, consistency, vascularity and histology. There was not difference in the histological pattern between local and diffuse recurrences. M.I. and Ki-67 LI were significantly correlated with the recurrence (P<0.0001). PR negativity had a strong predictive value of recurrence (P<0.0001), whereas the ER status was not relevant. VEGF and EGF-R were not correlated with the recurrence of meningiomas, whereas the Bcl-2 protein positivity showed a tendency to the significativity (P=0.0294). The negative association between Bcl-2 and PR is an interesting finding of our study.
conclusionsHigher MI and Ki-67 LI and PR negativity are predictive factors of recurrence of benign (WHO I) completely resected meningiomas, particularly when Bcl-2 positivity is associated.
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