ArticleThe Journal of membrane biology1991
Anion channels from rat brain synaptosomal membranes incorporated into planar bilayers.
Article in The Journal of membrane biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- ATP-sensitive anion channel from rat brain synaptosomal membranes incorporated into planar lipid bilayers.Biophysical journal · 1997Article
- A chloride channel reconstituted from fetal rat brain growth cones.The Journal of membrane biology · 1994Article
- Ion channels on synaptic vesicle membranes studied by planar lipid bilayer method.Biophysical journal · 1992Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic membranes from rat brain were incorporated into planar lipid bilayers, and the characteristics of two types of anion-selective channels (type I and type II) were investigated. In asymmetric BaCl2 buffers (cis, 100 mM/trans, 25 mM), single channel conductances at -40 mV were 70 pS (type I) and 120 pS (type II). Permeability ratios (PNa:PBa:PCl) calculated from the Goldman-Hodgkin-Katz current equation for type I and type II channels were 0.23:0.04:1 and 0.05:0.03:1, respectively. Both channels exhibited characteristic voltage-dependent bursting activities. Open probability for type I channels had a maximum of approximately 0.7 at about 0 mV and decreased to zero at greater transmembrane potentials of either polarity. Type II channels were relatively voltage independent at negative voltages and were inactivated at highly positive voltages. Type I channels showed spontaneous irreversible inactivation often preceded by sudden transition to subconducting states. DIDS blocked type I channels only from the cis side, while it blocked type II channels from either side.
Indexed as
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Registered trials
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