ReviewBritish journal of cancer2007
Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck.
Review in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Becotatug Vedotin: First Approval.Drugs · 2026Review
- The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data.Animal models and experimental medicine · 2023Review
- Recent development of surface-enhanced Raman scattering for biosensing.Journal of nanobiotechnology · 2023Review
- Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro.Molecules (Basel, Switzerland) · 2023Article
- M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway.Cell death & disease · 2022Article
- The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study.Cancer & metabolism · 2021Article
- Epidermal Growth Factor Receptor's Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies.Current treatment options in oncology · 2020Review
- The Oncogenic Activity ofJournal of clinical medicine · 2019Article
- Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2018Review
- NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.Journal of cancer research and clinical oncology · 2018Article
- Subpopulations of natural killer-T-like cells before and after surgical treatment of laryngeal cancer.Central-European journal of immunology · 2017Article
- Visualizing epithelial expression of EGFR in vivo with distal scanning side-viewing confocal endomicroscope.Scientific reports · 2016Article
- In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft.Photoacoustics · 2016Article
- Cannabis smoke can be a major risk factor for early-age laryngeal cancer--a molecular signaling-based approach.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging.Clinical and translational gastroenterology · 2015Article
- Evaluation of apoptogenic adenovirus type 5 oncolytic vectors in a Syrian hamster head and neck cancer model.Cancer gene therapy · 2014Article
- EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma.BMC cell biology · 2013Article
- Article
- Investigation of Th1/Th2 cytokine profiles in patients with laryngo-pharyngeal, HPV-positive cancers.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite significant advances in the use of surgery, chemotherapy and radiotherapy to treat squamous cell carcinoma of the head and neck (SCCHN), prognosis has improved little over the past 30 years. There is a clear need for novel, more effective therapies to prevent relapse, control metastases and improve overall survival. Improved understanding of SCCHN disease biology has led to the introduction of molecularly targeted treatment strategies in these cancers. The epidermal growth factor receptor (EGFR) is expressed at much higher levels in SCCHN tumours than in normal epithelial tissue, and EGFR expression correlates with poor prognosis. Therefore, much effort is currently directed toward targeting aberrant EGFR activity (e.g. cell signalling) in SCCHN. This review discusses the efficacy of novel therapies targeting the EGFR (e.g. anti-EGFR antibodies and EGFR tyrosine kinase inhibitors) that are currently tested in SCCHN patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.