ReviewThe pharmacogenomics journal2007
Overview of the pharmacogenomics of cigarette smoking.
Review in The pharmacogenomics journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 114 citations in OpenAlex.
- The serotonin transporter gene and startle response during nicotine deprivation.Biological psychology · 2011Trial
- Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.Translational psychiatry · 2023Article
- Nicotine Effects on White Matter Microstructure in Young Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women.BMC medical genetics · 2018Article
- Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.The pharmacogenomics journal · 2018Article
- Neuregulin signaling pathway in smoking behavior.Translational psychiatry · 2017Article
- GRONS: a comprehensive genetic resource of nicotine and smoking.Database : the journal of biological databases and curation · 2017Article
- Prioritizing Genes Related to Nicotine Addiction Via a Multi-source-Based Approach.Molecular neurobiology · 2015Article
- Review
- Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey.BMC public health · 2015Article
- A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.PLoS genetics · 2015Article
- CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence.Scientifica · 2015Review
- Genetics and smoking.Current addiction reports · 2014Article
- Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.Human molecular genetics · 2014Article
- Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci.Brain and behavior · 2014Article
- The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.Pharmacogenetics and genomics · 2013Article
- Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers.American journal of respiratory and critical care medicine · 2013Article
- Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats.Behavior genetics · 2013Article
- Article
- Do initial responses to drugs predict future use or abuse?Neuroscience and biobehavioral reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoking increases the risk of numerous health problems, including cancer, cardiovascular and pulmonary disorders, making smoking the leading cause of preventable death in the world. Nicotine is primarily responsible for the highly addictive properties of cigarettes. Although the majority of smokers express a desire to quit, few are successful in doing so. Twin and family studies have indicated substantial genetic contributions to smoking behaviors. One major research focus has been to elucidate the specific genes involved; this has been accomplished primarily through genome-wide linkage analyses and candidate gene association studies. Much attention has focused on genes involved in the neurotransmitter pathways for the brain reward system and genes altering nicotine metabolism. This paper reviews the current state of knowledge for genetic factors implicated in smoking behaviors, and examines how genetic variations may affect therapeutic outcomes for drugs used to assist smoking cessation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.