ArticleMechanisms of development2007
Identification of an upstream regulatory element reveals a novel requirement for Ind activity in maintaining ind expression.
Article in Mechanisms of development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- An inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors.Developmental biology · 2026Article
- Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.Genes & development · 2021Article
- Uncoupling neurogenic gene networks in theGenes & development · 2017Article
- Dorsal-ventral gene expression in the Drosophila embryo reflects the dynamics and precision of the dorsal nuclear gradient.Developmental cell · 2012Article
- Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression.Development (Cambridge, England) · 2011Article
- Ind represses msh expression in the intermediate column of the Drosophila neuroectoderm, through direct interaction with upstream regulatory DNA.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Identification of Ind transcription activation and repression domains required for dorsoventral patterning of the CNS.Mechanisms of development · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A maternally established gradient of nuclear Dorsal protein is the first step in subdivision of the Drosophila neurectoderm into stripes of homeodomain gene expression. Dorsal in combination with the EGF and TGFbeta signaling pathways are key regulators of the expression of the genes ventral nervous system defective (vnd), intermediate neuroblasts defective (ind), and muscle segment homeobox (msh) in the developing neurectoderm. These three genes encode homeodomain transcription factors that can repress each other, which ensures adjacent, non-overlapping expression domains. Expression of vnd, ind, and msh is maintained after decline in EGF and TGFbeta signaling, but the relevant positive transcriptional regulators have not yet been defined. Here, we show that Ind can bind DNA with the same sequence specificity as its murine ortholog Gsh1. We have identified a novel upstream regulatory element at the ind locus containing predicted Ind binding sites, and we show that Ind activity is both necessary and sufficient for reporter gene expression from this element. We conclude that Ind can act as a transcriptional activator, and that positive autoregulation of Ind is a mechanism for persistent ind expression within the developing embryonic nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.