ArticleJournal of inflammation (London, England)2007
CD4/CD8 ratio and cytokine levels of the BAL fluid in patients with bronchiectasis caused by sulfur mustard gas inhalation.
Article in Journal of inflammation (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 35 citations in OpenAlex.
- Comparative proteomic analysis of mustard lung as a complicated disease using systems biology approach.BMC pulmonary medicine · 2022Article
- Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: possible role of Th17 cells in chronic lung pathology.International immunopharmacology · 2012Article
- Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.Respiratory research · 2011Article
- Sulfur mustard induces expression of metallothionein-1A in human airway epithelial cells.International journal of general medicine · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze cytokine levels in BAL fluid of patients with bronchiectasis due to mustard gas inhalation. PATIENTS: 29 victims with mustard gas-induced bronchiectasis and 25 normal veterans as control group.
interventionPFTs,, high-resolution CT scans of the chest, analyses of BAL fluids for five cytokines (IL-8, IL-1beta, IL-6, TNF-alpha, IL-12) and analyses of BAL fluids for cellular and flow-cytometric analysis of the phenotype of bronchoalveolar cells were performed in all cases.
resultsCD4 lymphocytes expressed as percentage or absolute number were significantly higher in patients with bronchiectasis than in controls (32.17 +/- 16.00 vs 23.40 +/- 6.97%, respectively; p = 0.01; and 3.31 +/- 2.03 vs 1.88 +/- 0.83 x 10(3) cells/ml, respectively; p = 0.001). The CD4/CD8 ratio was significantly higher in patients with bronchiectasis than in controls (3.08 +/- 2.05 vs 1.68 +/- 0.78; p = 0.002). There were significant differences in cytokine (IL-8, IL-1beta, IL-6, TNF-alpha, IL-12) levels of BAL fluid between patients with bronchiectasis and healthy controls.A significant correlation was observed between the HRCT scores and both the percentage and the absolute number of CD4 lymphocytes in BAL fluid in patients with bronchiectasis (r = -0.49, p = 0.009; r = -0.50, p = 0.008; respectively). HRCT scores showed a significant correlation with CD4/CD8 ratios (r = 0.54, p = 0.004) too. Of measured BAL cytokines, only IL-8 (r = -0.52, p = 0.005) and TNF-aalpha (r = 0.44, p = 0.01) showed significant correlations with the HRCT scores.
conclusionThe increased levels of cytokines CD4 lymphocytes in the BAL fluid suggest the possible causative mechanism in the lung in sulfur mustard gas-induced bronchiectasis by the recruitment of neutrophils into the lung.
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