ArticleClinical endocrinology2007
The emergence of the cortisol circadian rhythm in monozygotic and dizygotic twin infants: the twin-pair synchrony.
Article in Clinical endocrinology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Heritability of Psychological Traits and Developmental Milestones in Infancy: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- NICU-based stress response and preterm infant neurobehavior: exploring the critical windows for exposure.Pediatric research · 2022Article
- Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis?The Journal of clinical endocrinology and metabolism · 2020Observational
- Human milk as "chrononutrition": implications for child health and development.Pediatric research · 2019Review
- Article
- Article
- Concordance of mother-daughter diurnal cortisol production: Understanding the intergenerational transmission of risk for depression.Biological psychology · 2015Article
- Development of Salivary Cortisol Circadian Rhythm and Reference Intervals in Full-Term Infants.PloS one · 2015Article
- The development of the circadian heart rate rhythm (CHR) in Asian infants.Early human development · 2012Article
- Prenatal tobacco and marijuana co-use: Sex-specific influences on infant cortisol stress response.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStudies on the influence of genetic factors on the ontogeny of cortisol circadian rhythm in infants are lacking. This study evaluated the influence of twinning and the heritability on the age of emergence of salivary cortisol rhythm. DESIGN AND SUBJECTS: A longitudinal study was performed using salivary samples obtained during morning and night, at 2, 4, 8, 12, 16, 20 and 24 weeks of postnatal life in 34 infants, 10 monozygotic (MZ) and 7 dizygotic (DZ) twin pairs. Salivary cortisol was determined by radioimmunoassay (RIA). Zigosity was verified by DNA analysis of at least 13 short tandem repeat polymorphisms. Difference of the emergence of cortisol circadian rhythm, within each twin pair, the intraclass correlation coefficient and the heritability index (h(2)) were calculated.
resultsThe mean (+/- SEM) age of emergence of salivary cortisol circadian rhythm was similar in MZ and DZ (7.8 +/- 1.0 vs 7.4 +/- 1.3 weeks). Seven pairs showed coincidence of the emergence of cortisol rhythm. Ten pairs were not coincident; among them the within-pair difference of emergence of salivary circadian rhythm was similar in both MZ and DZ groups. The intraclass correlation coefficients were rMZ = 0.60, P = 0.02; and rDZ = 0.65, P = 0.03, respectively. The heritability index (h(2)) was 0.21 (ns).
conclusionsSalivary circadian rhythm appeared at the same postnatal age in MZ and DZ twin infants. Although several physiological aspects might be involved, the heritability index, obtained in the present study, suggests less genetic than environmental impact on the age of the onset of the cortisol circadian rhythm. Our data also indicated that each twin-pair show synchrony because they probably shared prenatal and postnatal environmental synchronizers.
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