ArticleClinical and experimental immunology2007
Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis.Clinical and experimental immunology · 2015Trial
- Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases.Cell & bioscience · 2022Review
- Extrahepatic cancers and chronic HCV infection.Nature reviews. Gastroenterology & hepatology · 2018Review
- Role of macrophages and monocytes in hepatitis C virus infections.World journal of gastroenterology · 2014Review
- Role of hepatitis C virus in B cell lymphoproliferations.Virologica Sinica · 2014Review
- Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+, CD14+ and CD19+.Virology journal · 2013Article
- Autoimmune manifestations in viral hepatitis.Seminars in immunopathology · 2013Review
- B cell homeostasis in chronic hepatitis C virus-related mixed cryoglobulinemia is maintained through naïve B cell apoptosis.Hepatology (Baltimore, Md.) · 2012Article
- Molecular signature in HCV-positive lymphomas.Clinical & developmental immunology · 2012Review
- Biological significance of HCV in various kinds of lymphoid cells.International journal of microbiology · 2012Article
- Hepatitis C virus infection and mixed cryoglobulinemia.Clinical & developmental immunology · 2012Review
- Human cell types important for hepatitis C virus replication in vivo and in vitro: old assertions and current evidence.Virology journal · 2011Review
- Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.PloS one · 2011Article
- Hepatitis C virus infection and lymphoma.Mediterranean journal of hematology and infectious diseases · 2010Article
- Application of PCR-based methods to assess the infectivity of enteric viruses in environmental samples.Applied and environmental microbiology · 2009Article
- Hepatitis C virus and lymphoma.Journal of clinical pathology · 2007Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the occurrence of cryoglobulins and hepatitis C virus (HCV) productive infection in peripheral blood and bone marrow-derived lymphocytes was explored. HCV minus strand RNA, the viral replicative intermediate, was searched for by a polyA(+) tract strand-specific Tth-based reverse transcriptase-polymerase chain reaction (RT-PCR) in lymphoid cells of 46 patients with acute and chronic infection. The HCV minus strand was demonstrated in RNA extracted from six (13%) and five (11%) peripheral blood and bone marrow-derived lymphocytes, respectively. The HCV replicating form in lymphoid cells was associated strictly with mixed cryoglobulinaemia (MCG), in that it was found in six of 13 (46%) MCG patients, including two with B cell non-Hodgkin's lymphoma (NHL). No traces of HCV-negative strand RNA were found in four patients with acute hepatitis C, in 15 with chronic active hepatitis without extrahepatic disorders, in seven with monoclonal gammopathy of undetermined significance, and in seven with B-NHL without MCG. These results emphasize the direct role of the virus in the pathogenesis of MCG and support the contention that HCV is not specifically lymphotropic, its entry and replication in lymphoid cells being determined largely by selective interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.