ArticleBMJ (Clinical research ed.)2007
Oral chemotherapy safety practices at US cancer centres: questionnaire survey.
Article in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Adherence to Oral Antineoplastic Therapies.The oncologist · 2016Pooled it
- Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial.Nature medicine · 2022Trial
- Impacts of a navigation program based on health information technology for patients receiving oral anticancer therapy: the CAPRI randomized controlled trial.BMC health services research · 2017Trial
- Trial
- The RESILIENT Study: A Retrospective, Descriptive, Correlational Investigation of Correlates of Oral Endocrine Therapy Adherence in Older Women With Breast Cancer.Cancer medicine · 2026Article
- Perceptions of oncology healthcare professional providing care to older adults prescribed oral anticancer medications in the United States: A qualitative study.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2025Article
- Trends in the Dispensing of Oral Anti-Cancer Medications Across Australia Over 10 Years.Pharmacoepidemiology and drug safety · 2025Article
- Real-world data of cardio-oncologic interventions for cardiovascular adverse events with oral oncolytics.Cardio-oncology (London, England) · 2024Article
- Targeted Toxicities: Protocols for Monitoring the Adverse Events of Targeted Therapies Used in the Treatment of Non-Small Cell Lung Cancer.International journal of molecular sciences · 2023Review
- Patient, provider, and hospital factors associated with oral anti-neoplastic agent initiation and adherence in older patients with metastatic renal cell carcinoma.Journal of geriatric oncology · 2022Article
- Outpatient oral anticancer agent utilization and costs in Manitoba from 2003 to 2016: a population-based study.Canadian journal of public health = Revue canadienne de sante publique · 2021Article
- Impact of mobile applications on adherence to cancer treatment: a systematic review and meta-analysis protocol.BMJ open · 2019Article
- Article
- The relationship between patient activation, confidence to self-manage side effects, and adherence to oral oncolytics: a pilot study with Michigan oncology practices.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Multidisciplinary Optimization of Oral Chemotherapy Delivery at the University of Wisconsin Carbone Cancer Center.Journal of oncology practice · 2016Article
- Oral Chemotherapy in Patients with Hematological Malignancies-Care Process, Pharmacoeconomic and Policy Implications.Current hematologic malignancy reports · 2016Review
- Pharmaceutical care program for onco-hematologic outpatients: safety, efficiency and patient satisfaction.International journal of clinical pharmacy · 2016Article
- Improving the Safety of Oral Chemotherapy at an Academic Medical Center.Journal of oncology practice · 2016Article
- Oral antineoplastic agents: how do we care about adherence?British journal of clinical pharmacology · 2015Review
- Good Intentions, Uncertain Outcomes: Physician Dispensing in Offices and Clinics.P & T : a peer-reviewed journal for formulary management · 2015Article
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
objectiveTo characterise current safety practices for the use of oral chemotherapy.
designWritten questionnaire survey of pharmacy directors of cancer centres.
settingComprehensive cancer centres in the United States.
resultsRespondents from 42 (78%) of 54 eligible centres completed the survey, after consulting with 89 colleagues. Clinicians at 29 centres used handwritten prescriptions, two used preprinted paper prescriptions, and six used electronic systems for most oral chemotherapy prescribing. For six commonly used oral chemotherapies, on average 10 centres required a diagnosis on the prescription, 11 required the protocol number, four required the cycle number, nine required double checking by a second clinician, 14 required a calculation of body surface area, and 14 required a calculation of dose per square metre of body surface area. Only a third of centres requested patients' written informed consent when oral chemotherapy was given off protocol. Nearly a quarter (10) of centres had no formal process for monitoring patients' adherence. In the past year respondents at 10 centres reported at least one serious adverse drug event related to oral chemotherapy, and respondents at 13 centres reported a serious near miss.
conclusionFew of the safeguards routinely used for infusion chemotherapy have been adopted for oral chemotherapy at US cancer centres. There is currently no consensus at these centres about safe medication practices for oral chemotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.