ArticleBehavioural brain research2007
Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats.
Article in Behavioural brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine AFrontiers in pharmacology · 2018Article
- The effects of nucleus accumbens μ-opioid and adenosine 2A receptor stimulation and blockade on instrumental learning.Behavioural brain research · 2014Article
- Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.Purinergic signalling · 2013Article
- Caffeinated Alcoholic Beverages - An Emerging Trend in Alcohol Abuse.Journal of addiction research & therapy · 2013Article
- The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.Journal of the experimental analysis of behavior · 2012Review
- Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.Psychopharmacology · 2011Article
- Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat.Psychopharmacology · 2011Article
- Xanthines as adenosine receptor antagonists.Handbook of experimental pharmacology · 2011Review
- Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism.Neuroscience · 2010Article
- The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.Brain research · 2010Article
- Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism.Behavioural brain research · 2009Article
- The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure.Psychopharmacology · 2009Article
- The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists.Psychopharmacology · 2009Article
- Dopamine, behavioral economics, and effort.Frontiers in behavioral neuroscience · 2009Article
- Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats.Psychopharmacology · 2008Article
- Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake.Pharmacology, biochemistry, and behavior · 2008Article
- Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.Parkinsonism & related disorders · 2008Review
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
There is considerable evidence of interactions between adenosine A2A receptors and dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been shown to reverse the motor effects of DA antagonists in animal models. The D2 antagonist haloperidol produces parkinsonism in humans, and also induces motor effects in rats, such as suppression of locomotion. The present experiments were conducted to study the ability of the adenosine A2A antagonist MSX-3 to reverse the locomotor effects of acute or subchronic administration of haloperidol in rats. Systemic (i.p.) injections of MSX-3 (2.5-10.0 mg/kg) were capable of attenuating the suppression of locomotion induced by either acute or repeated (i.e., 14 day) administration of 0.5 mg/kg haloperidol. Bilateral infusions of MSX-3 directly into the nucleus accumbens core (2.5 microg or 5.0 microg in 0.5 microl per side) produced a dose-related increase in locomotor activity in rats treated with 0.5 mg/kg haloperidol either acutely or repeatedly. There were no overall significant effects of MSX-3 infused directly into the dorsomedial nucleus accumbens shell or the ventrolateral neostriatum. These results indicate that antagonism of adenosine A2A receptors can attenuate the locomotor suppression produced by DA antagonism, and that this effect may be at least partially mediated by A2A receptors in the nucleus accumbens core. These studies suggest that adenosine and dopamine systems interact to modulate the locomotor and behavioral activation functions of nucleus accumbens core.
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