ArticleImmunity2007
Identification of a T lineage-committed progenitor in adult blood.
Article in Immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed.
- Physiological Functions of Mcl-1: Insights From Genetic Mouse Models.Frontiers in cell and developmental biology · 2021Review
- The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.The Journal of experimental medicine · 2019Article
- IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Multicongenic fate mapping quantification of dynamics of thymus colonization.The Journal of experimental medicine · 2015Article
- The development and function of thymic B cells.Cellular and molecular life sciences : CMLS · 2015Review
- Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.The Journal of experimental medicine · 2015Article
- Developmental gene networks: a triathlon on the course to T cell identity.Nature reviews. Immunology · 2014Review
- Article
- Transcriptional control of early T and B cell developmental choices.Annual review of immunology · 2014Review
- Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.Nature immunology · 2014Article
- Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The transcriptional landscape of αβ T cell differentiation.Nature immunology · 2013Article
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.The Journal of experimental medicine · 2013Article
- Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cutting edge: Natural helper cells derive from lymphoid progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.Blood · 2011Article
- Signal integration and crosstalk during thymocyte migration and emigration.Nature reviews. Immunology · 2011Review
- Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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2 authors.
Funding
Abstract
With help of a hCD25 reporter controlled by pre-T cell receptor alpha (Ptcra) regulatory elements, T cell precursors were identified in peripheral blood. Sca-1(+)IL-7Ralpha(+)Flt3(-) precursors that were c-kit(lo)Thy-1(hi) generated T lineage cells when cultured on OP9-DL1 stromal cells and upon transfer into Rag2(-/-)Il2rg(-/-) mice. No B cells were generated in vivo and only few in vitro. These cells, which we call circulating T cell progenitors (CTP), were found at the same frequency in Foxn1(nu/nu) thymus-deficient mice and wild-type mice, indicating that they were pre- rather than postthymic. Inhibition of Notch-dependent transcription in vivo reduced the frequency of intrathymic early T cell progenitors (ETP), but not CTP, indicating that the latter are less Notch dependent. Thus, CTP represent T lineage-committed T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.