ArticleBiomaterials2007
Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The role of peptides in bone healing and regeneration: a systematic review.BMC medicine · 2016Pooled it
- Cell-based therapies for regenerating bone.Minerva ortopedica e traumatologica : organo ufficiale della Societa piemontese-ligure-lombarda di ortopedia e traumatologia · 2013Article
- Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology.Tissue engineering. Part B, Reviews · 2011Review
- Stem cell homing in musculoskeletal injury.Biomaterials · 2011Review
- Cell therapy in bone healing disorders.Orthopedic reviews · 2010Article
- [Cell therapy in bone-healing disorders].Der Orthopade · 2010Review
- The influence of tethered epidermal growth factor on connective tissue progenitor colony formation.Biomaterials · 2009Article
- Impact of order and disorder in RGD nanopatterns on cell adhesion.Nano letters · 2009Article
- Screening for 3D environments that support human mesenchymal stem cell viability using hydrogel arrays.Tissue engineering. Part A · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bone graft performance can be enhanced by addition of connective tissue progenitors (CTPs) from fresh bone marrow in a manner that concentrates the CTP cell population within the graft. Here, we used small peptide adhesion ligands presented against an otherwise adhesion-resistant synthetic polymer background in order to illuminate the molecular basis for the attachment and colony formation by osteogenic CTPs from fresh human marrow, and contrast the behavior of fresh marrow to many commonly used osteogenic cell sources. The linear GRGDSPY ligand was as effective as tissue culture polystyrene in fostering attachment of culture-expanded porcine CTPs. Although this GRGDSPY peptide was more effective than control peptides in fostering alkaline phosphatase (AP)-positive colony formation from primary human marrow in 5 of the 7 patients tested, GRGDSPY was as effective as the control glass substrate in only one patient of 7. Thus, the peptide appears capable of enabling osteoblastic development from only a subpopulation of CTPs in marrow. The bone sialoprotein-derived peptide FHRRIKA was ineffective in fostering attachment of primary culture-expanded pig CTPs, although it was as effective as GRGDSPY in fostering AP-positive colonies from fresh human marrow. This study provides insights into integrin-mediated behaviors of CTPs and highlights differences between freshly isolated marrow and culture-expanded cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.