ArticleDevelopmental biology2007
Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy · 2016Guideline
- Guideline
- mTOR signaling governs the formation of epithelial apical projections via S6K1-RhoA and aPKC-Lgl2 axes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death.Development (Cambridge, England) · 2024Article
- Article
- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research.Laboratory animal research · 2021Review
- The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish.Biology open · 2021Article
- Vitamin E Deficiency Disrupts Gene Expression Networks during Zebrafish Development.Nutrients · 2021Article
- Chloroquine Downregulation of Intestinal Autophagy to Alleviate Biological Stress in Early-Weaned Piglets.Animals : an open access journal from MDPI · 2020Article
- Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions.General and comparative endocrinology · 2019Article
- Roles of mTOR Signaling in Tissue Regeneration.Cells · 2019Review
- Dietary sulfur amino acids affect jejunal cell proliferation and functions by affecting antioxidant capacity, Wnt/β-catenin, and the mechanistic target of rapamycin signaling pathways in weaning piglets.Journal of animal science · 2018Article
- Effects of dietary poly-β-hydroxybutyrate (PHB) on microbiota composition and the mTOR signaling pathway in the intestines of litopenaeus vannamei.Journal of microbiology (Seoul, Korea) · 2017Article
- The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.Scientific reports · 2017Article
- Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways.Bioscience reports · 2017Article
- Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues.Disease markers · 2017Article
- Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter.Oncogene · 2016Article
- Frogs as integrative models for understanding digestive organ development and evolution.Seminars in cell & developmental biology · 2016Review
- TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.Cell death & disease · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The target of rapamycin (TOR) signaling pathway regulates cell growth and proliferation, however the extent to which TOR signaling mediates particular organogenesis programs remains to be determined. Here we report an examination of TOR signaling during zebrafish development, using a combination of small molecule treatment and morpholino-mediated gene knockdown. First, we amplified and sequenced the full-length cDNA for the zebrafish TOR ortholog (ztor). By in situ hybridization, we found that ztor is expressed ubiquitously in the early embryo, but displays a dynamic pattern in the gut between 48 and 72 h post-fertilization (hpf). Treatment of zebrafish embryos with rapamycin induced only a mild general developmental delay up to 72 hpf, but digestive tract development became arrested at the primitive gut tube stage. Rapamycin inhibited intestinal epithelial growth, morphogenesis and differentiation. Using morpholino-mediated gene knockdown of TOR pathway components, we show that this effect is mediated specifically by the rapamycin-sensitive TOR complex 1 (TORC1). Thus, in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the vertebrate intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.