ArticleInternational journal of experimental pathology2006
Recovery of rat submandibular salivary gland function following removal of obstruction: a sialometrical and sialochemical study.
Article in International journal of experimental pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Retroductal dexamethasone administration promotes the recovery from obstructive and inflammatory salivary gland dysfunction.Frontiers in immunology · 2024Article
- Impact of photobiomodulation therapy on the morphological aspects of submandibular gland submitted to excretory duct ligation and hypothyroidism: an animal study.Lasers in medical science · 2022Article
- Efficacy of corticosteroid ductal irrigation in acute salivary gland inflammation induced in a rat model.Imaging science in dentistry · 2022Article
- Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva.Journal of dental research · 2021Review
- Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature.Journal of clinical medicine · 2021Review
- Experimental Animal Model Systems for Understanding Salivary Secretory Disorders.International journal of molecular sciences · 2020Review
- P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction.Frontiers in pharmacology · 2020Review
- aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1.Scientific reports · 2018Article
- Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals.Stem cell reports · 2016Article
- Palliative Care for Salivary Gland Dysfunction Highlights the Need for Regenerative Therapies: A Review on Radiation and Salivary Gland Stem Cells.Journal of palliative care & medicine · 2014Article
- Regeneration of acinar cells following ligation of rat submandibular gland retraces the embryonic-perinatal pathway of cytodifferentiation.Differentiation; research in biological diversity · 2010Article
- Inducible nitric oxide synthase increases secretion from inflamed salivary glands.Rheumatology (Oxford, England) · 2010Article
- Altered plasticity of the parasympathetic innervation in the recovering rat submandibular gland following extensive atrophy.Experimental physiology · 2009Article
- Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation.Oral diseases · 2008Article
- Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, inflamed, atrophic and regenerative states.BMC molecular biology · 2008Article
- Early markers of regeneration following ductal ligation in rat submandibular gland.Cell and tissue research · 2008Article
- Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model.Journal of oral & maxillofacial researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional recovery of the rat submandibular gland following ligation of the main excretory duct was examined. Rat submandibular glands were ligated for 1, 4 and 8 weeks using a micro-clip with a plastic tube. Micro-clips were removed and glands were allowed to recover for periods of 8, 16 and 24 weeks. Submandibular glands were stimulated with autonomimetic drugs (methacholine and isoprenaline) and salivas were collected from atrophic or de-ligated and contralateral control glands. Glands recovered almost full size (92% of control gland) following 24 weeks of de-ligation. Saliva volume secreted by ligated/de-ligated (RSM) and control (LSM) glands were similar with different doses of agonists. Protein output expressed per gram of tissue wet weight was similar from both ligated/de-ligated and control glands with all doses of agonist. Sodium and chloride levels were higher from de-ligated glands than contralateral control glands. Protein electrophoresis showed similar profiles of salivary proteins in all samples with some minor differences. Acinar cells in de-ligated glands showed a normal morphology, as indicated by light microscopy, whilst granular ductal cells were fewer and contained fewer secretory granules. Sodium potassium ATPase staining of striated ducts in de-ligated glands was similar to that of control glands. It can be concluded that rat submandibular glands can regenerate following severe atrophy and secrete normal amounts of saliva containing broadly a full profile of secretory proteins. In contrast to acinar cells, ductal cells appear not to recover full function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.