ReviewArchivum immunologiae et therapiae experimentalis
Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation.
Review in Archivum immunologiae et therapiae experimentalis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of Dysglycemia on Urinary Lipid Mediator Profiles in Persons With Pulmonary Tuberculosis.Frontiers in immunology · 2022Observational
- Experimental Models of Infectious Pulmonary Complications Following Hematopoietic Cell Transplantation.Frontiers in immunology · 2021Review
- Effects of Hematopoietic Cell Transplantation on the Pulmonary Immune Response to Infection.Frontiers in pediatrics · 2021Review
- Prostaglandin EPharmacology & therapeutics · 2018Review
- Elevated prostaglandin EMucosal immunology · 2018Article
- Too much of a good thing: How modulating LTBSeminars in immunology · 2017Review
- Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system.Frontiers in immunology · 2013Article
- COX-2 expression is upregulated by DNA hypomethylation after hematopoietic stem cell transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi.Science signaling · 2012Article
- Cyclooxygenase inhibition in sepsis: is there life after death?Mediators of inflammation · 2012Review
- Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2.Respiratory research · 2011Article
- PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation.American journal of respiratory cell and molecular biology · 2011Article
- Impaired pulmonary immunity post-bone marrow transplant.Immunologic research · 2011Article
- A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant.Experimental lung research · 2008Article
- Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.Molecular pharmacology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for a number of malignant and inherited disorders. However, the efficacy of this therapy is limited by a number of serious infectious and noninfectious complications. Pulmonary infections represent a significant cause of morbidity and mortality post-HSCT and can occur both pre- and post-hematopoietic reconstitution. Susceptibility to Gram-negative bacterial infections despite full hematopoietic engraftment suggests that innate immunity remains impaired months to years post-HSCT. This review will describe the process and complications of HSCT and will summarize what is known about innate immune reconstitution post-HSCT. Data from the literature as well as our own laboratory will be presented to suggest that an eicosanoid imbalance characterized by over-production of prostaglandins and under-production of leukotrienes leads to impaired lung phagocyte function post-HSCT. Of therapeutic interest, strategies which limit production of prostaglandins can improve pulmonary host defense in animal HSCT models, which suggests that this may also be beneficial for human HSCT recipients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.