ArticlePlant cell reports2007
Sugars proportionately affect artemisinin production.
Article in Plant cell reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 78 citations in OpenAlex.
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- Establishment of feijoa (Frontiers in plant science · 2023Article
- Comparative transcriptome analysis provides insights into steviol glycoside synthesis in stevia (Stevia rebaudiana Bertoni) leaves under nitrogen deficiency.Plant cell reports · 2021Article
- Article
- Biotechnological approaches for artemisinin production in Artemisia.World journal of microbiology & biotechnology · 2018Review
- A Review of Biotechnological Artemisinin Production in Plants.Frontiers in plant science · 2017Review
- Enhanced Production of Anthraquinones and Phenolic Compounds and Biological Activities in the Cell Suspension Cultures of Polygonum multiflorum.International journal of molecular sciences · 2016Article
- Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production.Protoplasma · 2016Review
- Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.PloS one · 2015Article
- The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.Plant cell reports · 2013Article
- Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2011Article
- Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.In vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association · 2011Article
- Effect of sugars on artemisinin production in Artemisia annua L.: transcription and metabolite measurements.Molecules (Basel, Switzerland) · 2010Article
- Enhancement of artemisinin concentration and yield in response to optimization of nitrogen and potassium supply to Artemisia annua.Annals of botany · 2009Article
- Recent advances in artemisinin production through heterologous expression.Current medicinal chemistry · 2008Review
- Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways.Plant cell reports · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Little is known about the effect of sugars in controlling secondary metabolism. In this study, sugars alone or in combination with their analogs were used to investigate their role in the production of the antimalarial drug, artemisinin, in Artemisia annua L. seedlings. Compared to sucrose, a 200% increase in artemisinin by glucose was observed. Different ratios of fructose to glucose yielded artemisinin levels directly proportional to increases in relative glucose concentration. When the glucose analog, 3-O-methylglucose, was added with glucose, artemisinin production was dramatically decreased, but hexokinase activity was significantly increased compared to glucose alone. In contrast, neither mannose nor mannitol had any significant effect on artemisinin yield. In comparison with 30 g/l sucrose, artemisinin levels were significantly reduced by 80% in the presence of 27 g/l sucrose + 3 g/l palatinose, which cannot be transported into cells through the sucrose transporter. Together these results suggest that both monosaccharide and disaccharide sugars are likely acting not only as carbon sources but also as signals to affect the downstream production of artemisinin, and that the mechanism of these effects appears to be complex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.