ArticleDiabetologia2007
Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- The Influence of Microenvironment on Survival of Intraportal Transplanted Islets.Frontiers in immunology · 2022Review
- Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction.Molecular metabolism · 2020Article
- Article
- Article
- Purification of replicating pancreatic β-cells for gene expression studies.Scientific reports · 2017Article
- Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells.PloS one · 2015Article
- Achillea Millefolium L. Hydro- Alcoholic Extract Protects Pancreatic Cells by Down Regulating IL- 1β and iNOS Gene Expression in Diabetic Rats.International journal of molecular and cellular medicine · 2014Article
- MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.Journal of cellular and molecular medicine · 2011Article
- alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation.Journal of molecular and cellular cardiology · 2008Review
- Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.Molecular medicine (Cambridge, Mass.)Review
- The Role of Interleukin-1β in Destruction of Transplanted Islets.Cell transplantationReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisInterleukin-1 receptor antagonist (IL1RN, also known as IL1RA) is a naturally occurring inhibitor of IL-1 action and its overproduction protects pancreatic islets from the deleterious effects of IL-1beta on beta cell replication, apoptosis and function. The aim of this study was to determine whether viral gene transfer of the Il1rn gene into rat islets ex vivo had a beneficial effect on the outcome of the graft. MATERIALS AND
methodsStreptozotocin-diabetic Lewis rats were syngeneically transplanted with 500 or 800 Ad-Il1rn-infected or uninfected islets. Islet grafts were collected on day 3, 10 or 28 after transplantation and beta cell apoptosis, replication, size and mass were determined.
resultsAnimals transplanted with 500 islets remained hyperglycaemic throughout the follow-up, as expected. Beta cell replication increased in the Ad-Il1rn group on days 3, 10 and 28 after transplantation compared with normal pancreas. In uninfected islets, by contrast, beta cell replication was increased only on day 10. Beta cell apoptosis was increased in all transplanted groups; it was 25% lower in the Ad-Il1rn than in uninfected groups, but differences were not statistically significant. The initially transplanted beta cell mass was reduced on day 3, increasing subsequently in Ad-Il1rn grafts, but not in uninfected grafts. When 800 islets were transplanted, all animals grafted with Ad-Il1rn-infected islets, but only 40% of those transplanted with uninfected islets, achieved normoglycaemia 14 days after transplantation. CONCLUSIONS/
interpretationOverproduction of IL1RN increased beta cell replication and mass of islet grafts and reduced the beta cell number required to achieve normoglycaemia.
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