ArticleNature structural & molecular biology2007
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
Article in Nature structural & molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A synthetic scaffold to target peptide-MHC complexes.Nature biotechnology · 2025Article
- A general system for targeting MHC class II-antigen complex via a single adaptable loop.Nature biotechnology · 2025Article
- A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B.Human vaccines & immunotherapeutics · 2024Article
- Novel insights into the immune response to bacterial T cell superantigens.Nature reviews. Immunology · 2024Review
- A general platform for targeting MHC-II antigens via a single loop.bioRxiv : the preprint server for biology · 2024Article
- In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A.Journal of translational medicine · 2023Article
- Review
- Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading.PLoS pathogens · 2020Article
- A comprehensive mathematical model for three-body binding equilibria.Journal of the American Chemical Society · 2013Article
- Article
- Pfit is a structurally novel Crohn's disease-associated superantigen.PLoS pathogens · 2013Article
- T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- T cells and their eons-old obsession with MHC.Immunological reviews · 2012Review
- Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one.PloS one · 2011Article
- The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.The Journal of biological chemistry · 2011Article
- Staphylococcal superantigens cause lethal pulmonary disease in rabbits.The Journal of infectious diseases · 2010Article
- The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.Nature communications · 2010Article
- Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer.Journal of molecular biology · 2010Article
- Breaking the wall: targeting of the endothelium by pathogenic bacteria.Nature reviews. Microbiology · 2010Review
- Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl.Immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.