ArticleEukaryotic cell2007
A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1p.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism.Nucleic acids research · 2023Article
- Article
- The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.Scientific reports · 2017Article
- Characterization of RNA Helicase CshA and Its Role in Protecting mRNAs and Small RNAs of Staphylococcus aureus Strain Newman.Infection and immunity · 2016Article
- Candida albicans exhibits enhanced alkaline and temperature induction of Efg1-regulated transcripts relative to Candida dubliniensis.Genomics data · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- Heparin-binding motifs and biofilm formation by Candida albicans.The Journal of infectious diseases · 2013Article
- The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.PLoS genetics · 2012Article
- The NDR/LATS kinase Cbk1 controls the activity of the transcriptional regulator Bcr1 during biofilm formation in Candida albicans.PLoS pathogens · 2012Article
- An analysis of the impact of NRG1 overexpression on the Candida albicans response to specific environmental stimuli.Mycopathologia · 2010Article
- Mss11, a transcriptional activator, is required for hyphal development in Candida albicans.Eukaryotic cell · 2009Article
- Novel subfamily of mitochondrial HMG box-containing proteins: functional analysis of Gcf1p from Candida albicans.Microbiology (Reading, England) · 2009Article
- Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans.Molecular biology of the cell · 2008Article
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans.Molecular biology of the cell · 2008Article
- Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans.Eukaryotic cell · 2007Article
- Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.Eukaryotic cell · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To elucidate the molecular mechanisms controlling the expression of the hypha-specific adhesin gene HWP1 of Candida albicans, its promoter was dissected and analyzed using a green fluorescent protein reporter gene. A 368-bp region, the HWP1 control region (HCR), was critical for activation under hypha-inducing conditions and conferred developmental regulation to a heterologous ENO1 promoter. A more distal region of the promoter served to amplify the level of promoter activation. Using gel mobility shift assays, a 249-bp subregion of HCR, HCRa, was found to bind at least four proteins from crude extracts of yeasts and hyphae with differing binding patterns dependent on cell morphology. Four proteins with DNA binding activities were identified by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis after separation by anion-exchange and heparin-Sepharose chromatography. One protein with high similarity to Nhp6, an HMG1 family member in Saccharomyces cerevisiae, and another with weak similarity to an HMG-like condensation factor from Physarum polycephalum implicated changes in chromatin structure as a critical process in hypha-specific gene regulation. Proteins with strong homology to histones were also found. These studies are the first to identify proteins that bind to a DNA segment that confers developmental gene regulation in C. albicans and suggest a new model for hypha-specific gene regulation.
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