ArticleApplied and environmental microbiology2007
The presence of the internalin gene in natural atypically hemolytic Listeria innocua strains suggests descent from L. monocytogenes.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Genome Sequences of Hemolytic and Nonhemolytic Listeria innocua Strains from Human, Food, and Environmental Sources.Microbiology resource announcements · 2022Article
- Evidence of Virulent Multi-Drug Resistant and Biofilm-FormingPathogens (Basel, Switzerland) · 2022Article
- Distribution and Characteristics ofMicroorganisms · 2022Article
- Prevalence and transmission characteristics ofEmerging microbes & infections · 2021Article
- Landscape of Stress Response and Virulence Genes AmongFrontiers in microbiology · 2021Review
- Whole Genome Analysis of Three Multi-Drug ResistantFrontiers in microbiology · 2021Article
- Occurrence, Diversity ofMicroorganisms · 2020Article
- Predominance of DistinctMicroorganisms · 2020Article
- Bacteriocins ofToxins · 2020Article
- Atypical HemolyticInfection and immunity · 2019Article
- OrfX, a Nucleomodulin Required formBio · 2017Article
- Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection.PLoS pathogens · 2016Article
- Inhibitory Effect of Lactococcin BZ AgainstFood technology and biotechnology · 2016Article
- Atypical Listeria innocua strains possess an intact LIPI-3.BMC microbiology · 2014Article
- Phenotypic and genotypic characterization of atypical Listeria monocytogenes and Listeria innocua isolated from swine slaughterhouses and meat markets.BioMed research international · 2014Article
- Stress survival islet 1 (SSI-1) survey in Listeria monocytogenes reveals an insert common to listeria innocua in sequence type 121 L. monocytogenes strains.Applied and environmental microbiology · 2011Article
- Comparative genomics of the bacterial genus Listeria: Genome evolution is characterized by limited gene acquisition and limited gene loss.BMC genomics · 2010Article
- A population genetics-based and phylogenetic approach to understanding the evolution of virulence in the genus Listeria.Applied and environmental microbiology · 2010Article
- Listeria seeligeri isolates from food processing environments form two phylogenetic lineages.Applied and environmental microbiology · 2010Article
- Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.Infection and immunity · 2008Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The atypical hemolytic Listeria innocua strains PRL/NW 15B95 and J1-023 were previously shown to contain gene clusters analogous to the pathogenicity island (LIPI-1) present in the related foodborne gram-positive facultative intracellular pathogen Listeria monocytogenes, which causes listeriosis. LIPI-1 includes the hemolysin gene, thus explaining the hemolytic activity of the atypical L. innocua strains. No other L. monocytogenes-specific virulence genes were found to be present. In order to investigate whether any other specific L. monocytogenes genes could be identified, a global approach using a Listeria biodiversity DNA array was applied. According to the hybridization results, the isolates were defined as L. innocua strains containing LIPI-1. Surprisingly, evidence for the presence of the L. monocytogenes-specific inlA gene, previously thought to be absent, was obtained. The inlA gene codes for the InlA protein which enables bacterial entry into some nonprofessional phagocytic cells. PCR and sequence analysis of this region revealed that the flanking genes of the inlA gene at the upstream, 5'-end region were similar to genes found in L. monocytogenes serotype 4b isolates, whereas the organization of the downstream, 3'-end region was similar to that typical of L. innocua. Sequencing of the inlA region identified a small stretch reminiscent of the inlB gene of L. monocytogenes. The presence of two clusters of L. monocytogenes-specific genes makes it unlikely that PRL/NW 15B95 and J1-023 are L. innocua strains altered by horizontal transfer. It is more likely that they are distinct relics of the evolution of L. innocua from an ancestral L. monocytogenes, as postulated by others.
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