ArticleApplied and environmental microbiology2007
Effect of superoxide dismutase gene inactivation on virulence of Pseudomonas aeruginosa PAO1 toward the silkworm, Bombyx mori.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Deletion ofApplied and environmental microbiology · 2026Article
- Characterization of temporal expression of immune genes in female locust challenged by fungal pathogen,Frontiers in immunology · 2025Article
- 16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa.Scientific reports · 2024Article
- Monothiol Glutaredoxin Is Essential for Oxidative Stress Protection and Virulence in Pseudomonas aeruginosa.Applied and environmental microbiology · 2023Article
- Oxidative Stress Response inPathogens (Basel, Switzerland) · 2021Review
- Article
- Sublethal Paraquat Confers Multidrug Tolerance inFrontiers in microbiology · 2020Article
- Escaping the Phagocytic Oxidative Burst: The Role of SODB in the Survival ofFrontiers in microbiology · 2020Article
- Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa.Developmental and comparative immunology · 2019Article
- Dual Transcriptomics of Host-Pathogen Interaction of Cystic Fibrosis IsolateFrontiers in cellular and infection microbiology · 2018Article
- Review
- Role of Sod Gene in Response to Static Magnetic Fields in Pseudomonas aeruginosa.Current microbiology · 2017Article
- Antioxidant Defense Mechanisms in Pseudomonas aeruginosa: Role of Iron-Cofactored Superoxide Dismutase in Response to UV-C Radiations.Current microbiology · 2016Article
- Involvement of a 1-Cys peroxiredoxin in bacterial virulence.PLoS pathogens · 2014Article
- Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.Infection and immunity · 2014Article
- Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa.BMC genomics · 2013Article
- Promise for plant pest control: root-associated pseudomonads with insecticidal activities.Frontiers in plant science · 2013Article
- Expression and characterization of an iron-containing superoxide dismutase from Burkholderia pseudomallei.Journal of microbiology (Seoul, Korea) · 2012Article
- The endosymbiont Wolbachia pipientis induces the expression of host antioxidant proteins in an Aedes albopictus cell line.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of superoxide dismutase (SOD) in virulence against the silkworm, Bombyx mori, mutants of Pseudomonas aeruginosa PAO1 lacking manganese-SOD (PAO1sodM), iron-SOD (PAO1sodB), or both (PAO1sodMB) were generated. The mutants were injected into the hemocoel of B. mori. The virulence decreased in the order PAO1=PAO1sodM>PAO1sodB>PAO1sodMB. In particular, PAO1sodMB was avirulent at a dose of 10(5) cells or less. The sod double mutant PAO1sodMB was then complemented with either pSodM or pSodB in trans. In both the complemented strains, the virulence was partially restored. Of the two plasmids, pSodB contributed more to the virulence of P. aeruginosa against B. mori. The results of growth in B. mori hemolymph broth and microscopic analysis suggested that a longer lag phase and superoxide sensitivity correlated with decreased virulence in sod mutants. In conclusion, the SODs are required for full virulence of P. aeruginosa against B. mori and Fe-SOD is more important than Mn-SOD in the infection process.
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