ArticleThe Plant cell2007
PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 185 citations in OpenAlex.
- A conserved hexapeptide switch controls autoinhibition of plant cytosolic invertases.Nature plants · 2026Article
- Regulation of maize root growth by local phosphorus availability, sucrose metabolism, and partitioning.Annals of botany · 2025Article
- Plant cold acclimation and its impact on sensitivity of carbohydrate metabolism.NPJ systems biology and applications · 2025Article
- Genome-wide identification of invertase genes in sweetpotato and its response to nitrogen and planting densities.BMC plant biology · 2025Article
- Genome-Wide Identification and Expression Profiling of the Invertase Genes Involved in Sugar Metabolism and Accumulation inInternational journal of molecular sciences · 2025Article
- Trichome development of systemic developing leaves is regulated by a nutrient sensor-relay mechanism within mature leaves.Science advances · 2025Article
- Roles and Regulations of Acid Invertases in Plants: Current Knowledge and Future Perspectives.Plants (Basel, Switzerland) · 2025Review
- Excess glucose inhibits the cotyledon greening of etiolated seedlings.Plant signaling & behavior · 2024Article
- OsPIPK-FAB, A Negative Regulator in Rice Immunity Unveiled by OsMBL1 Inhibition.Rice (New York, N.Y.) · 2024Article
- Genome-wide analysis of the passion fruit invertase gene family reveals involvement of PeCWINV5 in hexose accumulation.BMC plant biology · 2024Article
- Sorbitol mediates age-dependent changes in apple plant growth strategy through gibberellin signaling.Horticulture research · 2024Article
- Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance.Biology direct · 2024Article
- The Silencing ofInternational journal of molecular sciences · 2024Article
- Divergent Retention of Sucrose Metabolism Genes after Whole Genome Triplication in the Tomato (Plants (Basel, Switzerland) · 2023Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Identification and expression analysis of invertase family genes during grape (Vitis vinifera L.) berry development under CPPU and GA treatment.Molecular genetics and genomics : MGG · 2023Article
- Phosphoinositides in plant-pathogen interaction: trends and perspectives.Stress biology · 2023Review
- Article
- Differential Effects of Ammonium (NHPlants (Basel, Switzerland) · 2022Article
- Integrated Analysis of Single-Molecule Real-Time Sequencing and Next-Generation Sequencing Eveals Insights into Drought Tolerance Mechanism ofInternational journal of molecular sciences · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidylinositol monophosphate 5-kinase (PIP5K) plays an essential role in coordinating plant growth, especially in response to environmental factors. To explore the physiological function of PIP5K, we characterized Arabidopsis thaliana PIP5K9, which is constitutively expressed. We found that a T-DNA insertion mutant, pip5k9-d, which showed enhanced PIP5K9 transcript levels, had shortened primary roots owing to reduced cell elongation. Transgenic plants overexpressing PIP5K9 displayed a similar root phenotype. Yeast two-hybrid assays identified a cytosolic invertase, CINV1, that interacted with PIP5K9, and the physiological relevance of this interaction was confirmed by coimmunoprecipitation studies using plant extracts. CINV1-deficient plants, cinv1, had reduced activities of both neutral and acid invertases as well as shortened roots. Invertase activities in pip5k9-d seedlings were also reduced, suggesting a negative regulation of CINV1 by PIP5K9. In vitro studies showed that PIP5K9 interaction indeed repressed CINV1 activities. Genome-wide expression studies revealed that genes involved in sugar metabolism and multiple developmental processes were altered in pip5k9-d and cinv1, and the altered sugar metabolism in these mutants was confirmed by metabolite profiling. Together, our results indicate that PIP5K9 interacts with CINV1 to negatively regulate sugar-mediated root cell elongation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.