ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2007
Metabolic and ionoregulatory responses of the Amazonian cichlid, Astronotus ocellatus, to severe hypoxia.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 77 citations in OpenAlex.
- The key mechanisms associated with the survival of Gulf toadfish, Opsanus beta, when in severe hypoxia.Journal of fish biology · 2025Article
- Metal Toxicity: Effects on Energy Metabolism in Fish.International journal of molecular sciences · 2024Review
- Effect of hypoxia and air-breathing restricted on respiratory physiology of air-breathing loach (Paramisgurnus dabryanus).Fish physiology and biochemistry · 2021Article
- Influence of hypoxia on biochemical aspects and on expression of genes related to oxygen-homeostasis of the Amazonian cichlid Astronotus ocellatus (Agassiz, 1831).Genetics and molecular biology · 2021Article
- Hypoxia attenuate ionic transport in the isolated gill epithelium of Carcinus maenas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish.Aquatic toxicology (Amsterdam, Netherlands) · 2019Article
- Intertidal triplefin fishes have a lower critical oxygen tension (PJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Acute hypoxia up-regulates HIF-1α and VEGF mRNA levels in Amazon hypoxia-tolerant Oscar (Astronotus ocellatus).Fish physiology and biochemistry · 2016Article
- Different Oxygen Stresses on the Responses of Branchial Morphology and Protein Expression in the Gills and Labyrinth Organ in the Aquatic Air-breathing Fish,Zoological studies · 2016Article
- Gill paracellular permeability and the osmorespiratory compromise during exercise in the hypoxia-tolerant Amazonian oscar (Astronotus ocellatus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Preferential intracellular pH regulation represents a general pattern of pH homeostasis during acid-base disturbances in the armoured catfish, Pterygoplichthys pardalis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Should I stay or should I go?: Physiological, metabolic and biochemical consequences of voluntary emersion upon aquatic hypoxia in the scaleless fish Galaxias maculatus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Article
- The effects of temperature on the physiological response to low oxygen in Atlantic sturgeon.Fish physiology and biochemistry · 2011Article
- Anoxia- and hypoxia-induced expression of LDH-A* in the Amazon Oscar, Astronotus crassipinis.Genetics and molecular biology · 2011Article
- Physiological response in the European flounder (Platichthys flesus) to variable salinity and oxygen conditions.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the metabolic and ionoregulatory responses of the Amazonian cichlid, Astronotus ocellatus, to 20 h exposure to severe hypoxia (0.37 +/- 0.19 mg O(2)/l; 4.6% air saturation) or 8 h severe hypoxia followed by 12 h recovery in normoxic water. During 20 h exposure to hypoxia, white muscle [ATP] was maintained at normoxic levels primarily through a 20% decrease in [creatine phosphate] (CrP) and an activation of glycolysis yielding lactate accumulation. Muscle lactate accumulation maintained cytoplasmic redox state ([NAD(+)]/[NADH]) and was associated with an inactivation of the mitochondrial enzyme pyruvate dehydrogenase (PDH). The inactivation of PDH was not associated with significant changes in cytoplasmic allosteric modulators ([ADP(free)], redox state, or [pyruvate]). Hypoxia exposure caused an approximately 65% decrease in gill Na(+)/K(+) ATPase activity, which was not matched by changes in Na(+)/K(+) ATPase alpha-subunit protein abundance indicating post-translational modification of Na(+)/K(+) ATPase was responsible for the decrease in activity. Despite decreases in gill Na(+)/K(+) ATPase activity, plasma [Na(+)] increased, but this increase was possibly due to a significant hemoconcentration and fluid shift out of the extracellular space. Hypoxia caused an increase in Na(+)/K(+) ATPase alpha-subunit mRNA abundance pointing to either reduced mRNA degradation during exposure to hypoxia or enhanced expression of Na(+)/K(+) ATPase alpha-subunit relative to other genes.
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