Evidence map›Paper›PMID 17218520›Full record

ArticleScience (New York, N.Y.)2007

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Jane M Carlton, Robert P Hirt, Joana C Silva, Arthur L Delcher, Michael Schatz, Qi Zhao, Jennifer R Wortman, Shelby L Bidwell, U Cecilia M Alsmark, Sébastien Besteiro and 55 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 412 papers.

0numbers the graph read from it
0cells of the map it votes in
412citing papers in PubMed
42.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

412 citing papers in PubMed, 837 citations in OpenAlex.

  1. Trial
  2. Review
  3. Trichomonas vaginalis cathepsin D-like aspartic proteinase (Tv-CatD) is regulated by iron at different levels.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  4. Impact of pH andProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Analysis ofMicroorganisms · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Evolution and ecology of commensal gut protists: recent advances.Current opinion in genetics & development · 2025
    Review
  20. A Multi-Omics Perspective onInternational journal of molecular sciences · 2025
    Review

352 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors at 1 institution in 9 countries.

Jane M CarltonInstitute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA. jane.carlton@med.nyu.edu
Robert P Hirt
Joana C Silva
Arthur L Delcher
Michael Schatz
Qi Zhao
Jennifer R Wortman
Shelby L Bidwell
U Cecilia M Alsmark
Sébastien Besteiro
Thomas Sicheritz-Ponten
Christophe J Noel
Joel B Dacks
Peter G Foster
Cedric Simillion
Yves Van de Peer
Diego Miranda-Saavedra
Geoffrey J Barton
Gareth D Westrop
Sylke Müller
Daniele Dessi
Pier Luigi Fiori
Qinghu Ren
Ian Paulsen
Hanbang Zhang
Felix D Bastida-Corcuera
Augusto Simoes-Barbosa
Mark T Brown
Richard D Hayes
Mandira Mukherjee
Cheryl Y Okumura
Rachel Schneider
Alias J Smith
Stepanka Vanacova
Maria Villalvazo
Brian J Haas
Mihaela Pertea
Tamara V Feldblyum
Terry R Utterback
Chung-Li Shu
Kazutoyo Osoegawa
Pieter J de Jong
Ivan Hrdy
Lenka Horvathova
Zuzana Zubacova
Pavel Dolezal
Shehre-Banoo Malik
John M Logsdon
Katrin Henze
Arti Gupta
Ching C Wang
Rebecca L Dunne
Jacqueline A Upcroft
Peter Upcroft
Owen White
Steven L Salzberg
Petrus Tang
Cheng-Hsun Chiu
Ying-Shiung Lee
T Martin Embley
Graham H Coombs
Jeremy C Mottram
Jan Tachezy
Claire M Fraser-Liggett
Patricia J Johnson
Human Genome Sciences (United States) · US

Funding

COMPUTATIONAL MODELING OF GENES AND GENE STRUCTURER01LM006845 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 1999 to 2010
$5.9M
Shotgun Sequencing of the Trichomonas Vaginalis GenomeU01AI050913 · NIAID · INSTITUTE FOR GENOMIC RESEARCH · PI CARLTON, JANE · 2002 to 2003
$2.8M
Bioinformatics Software for Analyzing Microbial GenomesR01LM007938 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 2003 to 2006
$757k
Medical Research Council G0000508Medical Research Council G0000508(56841)Medical Research Council G9722968Medical Research Council G9722968(65078)NIAID NIH HHS U01 AI050913NIAID NIH HHS UO1 AI50913-01NLM NIH HHS R01 LM006845NLM NIH HHS R01 LM007938Wellcome Trust 072031
6 · The paper itself

Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Indexed as

Genome, ProtozoanSequence Analysis, DNAAnimalsBiological TransportDNA, ProtozoanDNA Transposable ElementsGenes, ProtozoanGene Transfer, HorizontalHumansHydrogenMetabolic Networks and PathwaysMolecular Sequence DataMultigene FamilyOrganellesOxidative StressPeptide HydrolasesDNA, ProtozoanDNA Transposable ElementsHydrogenPeptide HydrolasesProtozoan Proteins

Identifiers

PMID17218520
PMCPMC2080659
OpenAlexW2163524749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.