ArticleBiophysical journal2007
Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Oxygen flux from capillary to mitochondria: integration of contemporary discoveries.European journal of applied physiology · 2022Review
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Differential Interaction of Myoglobin with Select Fatty Acids of Carbon Chain Lengths C8 to C16.Lipids · 2017Article
- Effect of fatty acid interaction on myoglobin oxygen affinity and triglyceride metabolism.Journal of physiology and biochemistry · 2016Article
- Interaction of myoglobin with oleic acid.Chemistry and physics of lipids · 2015Article
- Palmitate interaction with physiological states of myoglobin.Biochimica et biophysica acta · 2014Article
- Facilitated diffusion of myoglobin and creatine kinase and reaction-diffusion constraints of aerobic metabolism under steady-state conditions in skeletal muscle.Biotechnology and bioengineering · 2012Article
- Molecules in motion: influences of diffusion on metabolic structure and function in skeletal muscle.The Journal of experimental biology · 2011Review
- Myoglobin's old and new clothes: from molecular structure to function in living cells.The Journal of experimental biology · 2010Review
- Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Oximetry with the NMR signals of hemoglobin Val E11 and Tyr C7.European journal of applied physiology · 2009Article
- Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart.BMC systems biology · 2009Article
- Theoretical models of microvascular oxygen transport to tissue.Microcirculation (New York, N.Y. : 1994) · 2008Review
- Interaction of fatty acid with myoglobin.FEBS letters · 2008Article
- Determination of myoglobin concentration in blood-perfused tissue.European journal of applied physiology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pulsed field gradient NMR methods have determined the temperature-dependent diffusion of myoglobin (Mb) in perfused rat myocardium. Mb diffuses with an averaged translational diffusion coefficient (DMb) of 4.24-8.37x10(-7)cm2/s from 22 degrees C to 40 degrees C and shows no orientation preference over a root mean-square displacement of 2.5-3.5 microm. The DMb agrees with the value predicted by rotational diffusion measurements. Based on the DMb, the equipoise diffusion PO2, the PO2 in which Mb-facilitated and free O2 diffusion contribute equally to the O2 flux, varies from 2.72 to 0.15 in myocardium and from 7.27 to 4.24 mmHg in skeletal muscle. Given the basal PO2 of approximately 10 mmHg, the Mb contribution to O2 transport appears insignificant in myocardium. In skeletal muscle, Mb-facilitated diffusion begins to contribute significantly only when the PO2 approaches the P50. In marine mammals, the high Mb concentration confers a predominant role for Mb in intracellular O2 transport under all physiological conditions. The Q10 of the DMb ranges from 1.3 to 1.6. The Mb diffusion data indicate that the postulated gel network in the cell must have a minimum percolation cutoff size exceeding 17.5 A and does not impose tortuosity within the diffusion root mean-square displacement. Moreover, the similar Q10 for the DMb of solution versus cell Mb suggests that any temperature-dependent alteration of the postulated cell matrix does not significantly affect protein mobility.
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