ArticleThe Journal of physiology2007
Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs.The Cochrane database of systematic reviews · 2017Pooled it
- The effects of sildenafil and acetazolamide on breathing efficiency and ventilatory control during hypoxic exercise.European journal of applied physiology · 2009Trial
- Effects of acetazolamide on exercise performance in patients with COPD going to high altitude: randomised controlled trial.ERJ open research · 2025Article
- Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide.Frontiers in cardiovascular medicine · 2025Article
- Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis.Frontiers in pharmacology · 2022Article
- Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches.Comprehensive Physiology · 2020Review
- Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.BMJ open sport & exercise medicine · 2020Article
- Intra-pulmonary arteriovenous anastomoses and pulmonary gas exchange: evaluation by microspheres, contrast echocardiography and inert gas elimination.The Journal of physiology · 2019Article
- Precapillary pulmonary gas exchange is similar for oxygen and inert gases.The Journal of physiology · 2019Article
- Acetazolamide reduces exercise capacity following a 5-day ascent to 4559 m in a randomised study.BMJ open sport & exercise medicine · 2018Article
- Effects of low-dose acetazolamide on exercise performance in simulated altitude.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Acetazolamide during acute hypoxia improves tissue oxygenation in the human brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Increased cardiac output, not pulmonary artery systolic pressure, increases intrapulmonary shunt in healthy humans breathing room air and 40% O2.The Journal of physiology · 2014Article
- New insights into carbonic anhydrase inhibition, vasodilation, and treatment of hypertensive-related diseases.Current hypertension reports · 2014Review
- Acetazolamide pre-treatment before ascending to high altitudes: when to start?International journal of clinical and experimental medicine · 2014Article
- Acetazolamide attenuates transvascular fluid flux in equine lungs during intense exercise.The Journal of physiology · 2013Article
- Pulmonary gas exchange and acid-base balance during exercise.Comprehensive Physiology · 2013Review
- Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Acetazolamide (ACZ) is used to prevent acute mountain sickness at altitude. Because it could affect O2 transport in several different and potentially conflicting ways, we examined its effects on pulmonary and muscle gas exchange and acid-base status during cycle exercise at approximately 30, 50 and 90% VO2max in normoxia (F(IO2) = 0.2093) and acute hypoxia (F(IO2) = 0.125). In a double-blind, order-balanced, crossover design, six healthy, trained men (normoxic VO2max= 59 ml kg(-1) min(-1)) exercised at both F(IO2) values after ACZ (3 doses of 250 mg, 8 h apart) and placebo. One week later this protocol was repeated using the other drug (placebo or ACZ). We measured cardiac output (QT), leg blood flow (LBF), and muscle and pulmonary gas exchange, the latter using the multiple inert gas elimination technique. ACZ did not significantly affect VO2, QT, LBF or muscle gas exchange. As expected, ACZ led to lower arterial and venous blood [HCO3-], pH and lactate levels (P < 0.05), and increased ventilation (P < 0.05). In both normoxia and hypoxia, ACZ resulted in higher arterial P(O2) and saturation and a lower alveolar-arterial P(O2) difference (AaD(O2)) due to both less VA/Q mismatch and less diffusion limitation (P < 0.05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.