ArticleGenomics2007
Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.
Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 34 citations in OpenAlex.
- Single Nucleotide Polymorphism ofHypertension (Dallas, Tex. : 1979) · 2020Article
- Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Targeted disruption of regulated endocrine-specific protein ( Resp18) in Dahl SS/Mcw rats aggravates salt-induced hypertension and renal injury.Physiological genomics · 2018Article
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA.PLoS genetics · 2017Article
- Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3.Scientific reports · 2017Article
- High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass.Physiological genomics · 2016Article
- Article
- Multiple blood pressure loci with opposing blood pressure effects on rat chromosome 1 in a homologous region linked to hypertension on human chromosome 15.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains.Physiological genomics · 2013Article
- Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria.American journal of physiology. Heart and circulatory physiology · 2013Article
- Molecular mechanisms of experimental salt-sensitive hypertension.Journal of the American Heart Association · 2012Article
- Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models.Hypertension research : official journal of the Japanese Society of Hypertension · 2011Article
- Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock.Current genomics · 2011Article
- Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain.Physiological genomics · 2010Article
- Mitochondrial polymorphisms in rat genetic models of hypertension.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.Physiological genomics · 2009Article
- Closely linked non-additive blood pressure quantitative trait loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The presence of blood pressure (BP) quantitative trait loci (QTL) on rat chromosome 10 has been clearly demonstrated by linkage analysis and substitution mapping. Using congenic strains containing the LEW rat chromosomal segments on the Dahl salt-sensitive (S) rat background, further iterations of congenic substrains were constructed and characterized to fine-map a chromosome 10 region (QTL1) linked to blood pressure. Comparison of seven congenic substrains refined QTL1 to a 1.17 Mb segment flanked by D10Mco88 and D10Mco89, which are located at 71,513,116 and 72,684,774 bp, respectively. The newly defined QTL1, containing 18 genes, is captured in its entirety within a single congenic substrain. A thorough transcript analysis revealed that 3 of these 18 genes, Ccl5, Ddx52, and RGD1559577, had nonsynonymous allelic variations between the S rat and the LEW rat. None of the detected transcripts within the newly defined QTL1 are implicated directly in BP control in humans or model organisms. Therefore, the present work defines a novel blood pressure QTL with three potential quantitative trait nucleotides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.