ArticleRespiratory research2007
Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study.
Article in Respiratory research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.Current allergy and asthma reports · 2018Pooled it
- Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review.Thorax · 2008Pooled it
- Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates.Environmental health : a global access science source · 2023Article
- Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function.Frontiers in molecular biosciences · 2022Review
- Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.Journal of medical virology · 2021Article
- Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations.Chronic diseases and translational medicine · 2021Review
- Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure.Respiratory research · 2017Article
- [COPD: An early disease].Revue de pneumologie clinique · 2016Review
- Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population.Journal of medical biochemistry · 2015Article
- Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene.Scientific reports · 2013Article
- Effect of GSTM2-5 polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study.BMC pulmonary medicine · 2013Article
- NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.Physiological genomics · 2012Article
- Genome-wide association study of lung function decline in adults with and without asthma.The Journal of allergy and clinical immunology · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Glutathione S-transferase copy number variation alters lung gene expression.The European respiratory journal · 2011Article
- GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?The application of clinical genetics · 2011Article
- Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities.Pharmacogenomics · 2010Review
- Genetics and genomics of chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2009Review
- Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect.Environmental health perspectives · 2009Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the environmental and genetic risk factors of accelerated lung function decline in the general population is a first step in a prevention strategy against the worldwide increasing respiratory pathology of chronic obstructive pulmonary disease (COPD). Deficiency in antioxidative and detoxifying Glutathione S-transferase (GST) gene has been associated with poorer lung function in children, smokers and patients with respiratory diseases. In the present study, we assessed whether low activity variants in GST genes are also associated with accelerated lung function decline in the general adult population.
methodsWe examined with multiple regression analysis the association of polymorphisms in GSTM1, GSTT1 and GSTP1 genes with annual decline in FEV1, FVC, and FEF25-75 during 11 years of follow-up in 4686 subjects of the prospective SAPALDIA cohort representative of the Swiss general population. Effect modification by smoking, gender, bronchial hyperresponisveness and age was studied.
resultsThe associations of GST genotypes with FEV1, FVC, and FEF25-75 were comparable in direction, but most consistent for FEV1. GSTT1 homozygous gene deletion alone or in combination with GSTM1 homozygous gene deletion was associated with excess decline in FEV1 in men, but not women, irrespective of smoking status. The additional mean annual decline in FEV1 in men with GSTT1 and concurrent GSTM1 gene deletion was -8.3 ml/yr (95% confidence interval: -12.6 to -3.9) relative to men without these gene deletions. The GSTT1 effect on the FEV1 decline comparable to the observed difference in FEV1 decline between never and persistent smoking men. Effect modification by gender was statistically significant.
conclusionOur results suggest that genetic GSTT1 deficiency is a prevalent and strong determinant of accelerated lung function decline in the male general population.
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