ArticleVirology journal2007
Molecular analysis of hepatitis B virus "a" determinant in asymptomatic and symptomatic Mexican carriers.
Article in Virology journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- HBV genotype distribution and S gene mutations in HIV-HBV co-infected patients: insights from North India.Frontiers in cellular and infection microbiology · 2025Article
- Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions.Biomedicines · 2023Review
- Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication.Biomedicines · 2021Article
- Serological and molecular characterization of hepatitis B virus in asymptomatic blood donors in Iran.Iranian journal of microbiology · 2018Article
- Article
- Current hepatitis B virus infection situation in Indonesia and its genetic diversity.World journal of gastroenterology · 2016Review
- Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA.Hepatitis monthly · 2016Article
- Hepatitis B virus infection in Latin America: a genomic medicine approach.World journal of gastroenterology · 2014Review
- New perspective on the natural course of chronic HBV infection.Frontiers of medicine · 2014Review
- HBV endemicity in Mexico is associated with HBV genotypes H and G.World journal of gastroenterology · 2013Review
- Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.The American journal of tropical medicine and hygiene · 2010Article
- Use of dried blood samples for monitoring hepatitis B virus infection.Virology journal · 2009Article
- Surface gene variants of hepatitis B Virus in Saudi Patients.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B virus (HBV) is a small DNA-containing virus with 4 genes, C, S, X and P. The S gene codes for the surface antigen (HBsAg), which contains the "a" determinant, the main region for induction of a protective humoral immune response. To compare the genotype and sequence of the "a" determinant between strains isolated from asymptomatic and symptomatic Mexican HBV carriers.
results21 asymptomatic (blood donors) and 12 symptomatic (with clinical signs and with >1 year lamivudine treatment) HBV carriers were studied; all patients were positive for the HBsAg in serum. Viral load, genotypes, and subtypes were determined in plasma. A fragment of the S gene including the "a" determinant was PCR amplified and sequenced to determine genotype, subtype and to identify mutations. Mean viral load was 0.7965 x 104 copies/ml in asymptomatic carriers and 2.73 x 106 copies/ml in symptomatic patients. Genotypes H, C, and F were identified in asymptomatic individuals; whereas H was dominant in symptomatic patients. A fragment of 279 bp containing the "a" determinant was amplified from all 33 carriers and sequences aligned with S gene sequences in the GenBank. Mutations identified were Y100N, T126I, Q129H and N146K in the asymptomatic group, and F93I and A128V in the symptomatic group.
conclusionDifferences in genotype and in mutations in the "a" determinant were found between strains from asymptomatic and symptomatic HBV Mexican carriers.
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