ArticleJournal of physiology and biochemistry2006
Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity.
Article in Journal of physiology and biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity--a prospective study of three independent cohorts.Nutrition journal · 2014Trial
- Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model.Genes & nutrition · 2022Article
- Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia.Antioxidants (Basel, Switzerland) · 2020Article
- Glucose transporter 10 modulates adipogenesis via an ascorbic acid-mediated pathway to protect mice against diet-induced metabolic dysregulation.PLoS genetics · 2020Article
- Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice.International journal of obesity (2005) · 2019Article
- Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats.Yonsei medical journal · 2018Article
- Differential fecal microbiota are retained in broiler chicken lines divergently selected for fatness traits.Scientific reports · 2016Article
- Inflammation, Oxidative Stress, and Antioxidants Contribute to Selected Sleep Quality and Cardiometabolic Health Relationships: A Cross-Sectional Study.Mediators of inflammation · 2015Article
- Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice.Genes & nutrition · 2014Article
- Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet.Lipids in health and disease · 2014Article
- Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool.Frontiers in cell and developmental biology · 2014Article
- Dietary supplementation with phytosterol and ascorbic acid reduces body mass accumulation and alters food transit time in a diet-induced obesity mouse model.Lipids in health and disease · 2011Article
- Developmental programming in response to maternal overnutrition.Frontiers in genetics · 2011Article
- Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats.Diabetes · 2010Article
- High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats.Journal of physiology and biochemistry · 2009Article
- The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.BMC medical genomics · 2008Article
- Inhibition of serum cholesterol oxidation by dietary vitamin C and selenium intake in high fat fed rats.Lipids · 2008Article
- Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers.Molecular and cellular biochemistry · 2007Article
- Mitochondrial oxidative stress and inflammation: an slalom to obesity and insulin resistance.Journal of physiology and biochemistry · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is considered as an inflammatory disease, in which free radical-induced oxidative stress and excessive intake of macronutrients exacerbate their symptoms. In this context, we assessed in rats the possible preventive effect of the supplementation with an antioxidant molecule, ascorbic acid, in order to reduce the adiposity induced by the intake of a high-fat diet. For this purpose, during 56 days, three groups of male Wistar rats were fed on: a) standard pelleted diet, b) Cafeteria diet, c) ascorbate-supplemented (750 mg/kg of body weight) Cafeteria diet. At the end of the experimental period, microarray analysis was used to identify genes transcriptionally induced or repressed by both experimental dietary models (Cafeteria diet supplemented or not with ascorbic acid) in subcutaneous adipose tissue. Dietary ascorbic acid was able to protect against high fat diet effects, reducing the increase of body weight, total body fat and enlargement of different adipose depots induced by the Cafeteria diet without affecting food intake. An association analysis accurately and differentially allowed the detection of gene expression changes related with adiposity and insulin resistance. The genes that more strongly correlated with body fat and HOMA insulin resistance index were involved in adipocyte differentiation, lipid and glucocorticoid metabolism, cell cycle regulation, as well as in several insulin-induced processes. Some other transcripts are regulated by the vitamin C-mediated reduction of adiposity, such as genes that participate in glucocorticoid metabolism, adipogenesis, pentose phosphate pathway, or tricarboxylic acid cycle. This strategy was able to link variations in adipose tissue gene expression with markers of diet-induced obesity in rats, such as insulin resistance and body fat content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.