ArticleParasitology research2007
Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep.
Article in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Population genetic analysis of the liver fluke Fasciola hepatica in German dairy cattle reveals high genetic diversity and associations with fluke size.Parasites & vectors · 2025Article
- Intra- and interspecies variation and population dynamics of Fasciola gigantica among ruminants in Sudan.Parasitology research · 2024Article
- New Insights Into the Genetic Variability ofHelminthologia · 2022Article
- Pathogenicity and virulence of the liver flukesVirulence · 2021Article
- Evidence of population structuring following population genetic analyses of Fasciola hepatica from Argentina.International journal for parasitology · 2021Article
- Genetic diversity of Fasciola hepatica in Austria.Parasitology research · 2020Article
- Drug resistance in liver flukes.International journal for parasitology. Drugs and drug resistance · 2020Review
- Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance.International journal for parasitology · 2017Article
- Genetic characterization of Fasciola gigantica from different geographical regions of India by ribosomal DNA markers.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance.Parasitology research · 2014Article
- Molecular and Morphological Characterization of Fasciola spp. Isolated from Different Host Species in a Newly Emerging Focus of Human Fascioliasis in Iran.Veterinary medicine international · 2014Article
- The global burden of fasciolosis in domestic animals with an outlook on the contribution of new approaches for diagnosis and control.Parasitology research · 2013Review
- Article
- Characterization of Fasciola hepatica genotypes from cattle and sheep in Iran using cytochrome C oxidase gene (CO1).Parasitology research · 2012Article
- A comparative study of karyotypes and chromosomal location of rDNA genes in important liver flukes Fasciola hepatica and Fascioloides magna (Trematoda: Fasciolidae).Parasitology research · 2011Article
- Genetic characterization, species differentiation and detection of Fasciola spp. by molecular approaches.Parasites & vectors · 2011Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes.
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