ArticleDevelopment genes and evolution2007
RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera).
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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113 citing papers in PubMed, 250 citations in OpenAlex.
- Roles of the chemosensory protein RpCSP8 in reproduction and feeding behavior of sexual and non-sexual female of Rhopalosiphum padi.Insect science · 2026Article
- Odorant-binding proteins and chemosensory proteins in insects: structural insights, functional plasticity, and prospects for targeted pest management.Molecular biology reports · 2026Review
- Review
- Molecular Phylogeny of "Chemosensory Proteins" in Bacteria and Arthropods: CSP as an Extremely Ancient Gene.Journal of molecular evolution · 2026Article
- Article
- The Chemoreceptive Molecular Mechanism Underlying CSP-Mediated Recognition of Seed Elaiosome fromGenes · 2025Article
- Olfactory binding proteins: a review across the Insecta.Frontiers in zoology · 2025Review
- Review
- Deciphering the Olfactory Mechanisms ofInsects · 2025Article
- Elucidation of ejaculatory bulb proteins in Bemisia tabaci Asia-1 and Asia II-1 and confirmation of their mating transfer via RNAi.Molecular biology reports · 2024Article
- Molecular Characterization of Chemosensory Protein (CSP) Genes and the Involvement ofInternational journal of molecular sciences · 2024Article
- Odorant-Binding and Chemosensory Proteins in Fig Wasps: Evolutionary Insights From Comparative Studies.Journal of molecular evolution · 2024Article
- Article
- Comparative Transcriptomic Assessment of Chemosensory Genes in Adult and Larval Olfactory Organs ofGenes · 2023Article
- Transcriptome analysis used to identify and characterize odorant binding proteins in Agasicles hygrophila (Coleoptera: Chryspmelidae).Journal of insect science (Online) · 2023Article
- Expression Pattern and Ligand Binding Characteristics Analysis of Chemosensory Protein SnitCSP2 fromInsects · 2023Article
- Odorant-Binding Proteins and Chemosensory Proteins inInternational journal of molecular sciences · 2023Article
- Antennal Transcriptome Analysis of Olfactory Genes and Characterization of Odorant Binding Proteins inInternational journal of molecular sciences · 2023Article
- Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
53 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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Abstract
Small chemosensory proteins (CSPs) belong to a conserved, but poorly understood, protein family found in insects and other arthropods. They exhibit both broad and restricted expression patterns during development. In this paper, we used a combination of genome annotation, transcriptional profiling and RNA interference to unravel the functional significance of a honeybee gene (csp5) belonging to the CSP family. We show that csp5 expression resembles the maternal-zygotic pattern that is characterized by the initiation of transcription in the ovary and the replacement of maternal mRNA with embryonic mRNA. Blocking the embryonic expression of csp5 with double-stranded RNA causes abnormalities in all body parts where csp5 is highly expressed. The treated embryos show a "diffuse", often grotesque morphology, and the head skeleton appears to be severely affected. They are 'unable-to-hatch' and cannot progress to the larval stages. Our findings reveal a novel, essential role for this gene family and suggest that csp5 (unable-to-hatch) is an ectodermal gene involved in embryonic integument formation. Our study confirms the utility of an RNAi approach to functional characterization of novel developmental genes uncovered by the honeybee genome project and provides a starting point for further studies on embryonic integument formation in this insect.
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