ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2007
Osteoclasts prefer aged bone.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimization of high-intensity resistance exercise protocols for improving bone mineral density in the elderly without chronic diseases: a systematic review and network meta-analysis.Frontiers in physiology · 2025Pooled it
- Effects of PTH and alendronate on type I collagen isomerization in postmenopausal women with osteoporosis: the PaTH study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Trial
- 3D morphological analysis of age and sex-related changes in human cortical bone remodeling spaces using micro-CT.Journal of anatomy · 2026Article
- Mechanical Stimulation Drives Multicellular Synergy and Signaling Pathways in Developing Skeletal Tissues.Sports medicine (Auckland, N.Z.) · 2026Review
- Cellular senescence and other age-related mechanisms in skeletal diseases.Bone research · 2025Review
- Discoidin Domain Receptor 1 impacts bone microarchitecture with aging in female mice.JBMR plus · 2025Article
- Age and Gender Estimation Using the Osseous Microanatomy: Original Research.Journal of pharmacy & bioallied sciences · 2024Article
- Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies.Macromolecular bioscience · 2024Review
- Effects of Vitamin A (Retinol) Release from Calcium Phosphate Matrices and Porous 3D Printed Scaffolds on Bone Cell Proliferation and Maturation.ACS applied bio materials · 2022Article
- Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway.Bioactive materials · 2022Article
- Mesenchymal Stem Cell Transplantation for the Treatment of Age-Related Musculoskeletal Frailty.International journal of molecular sciences · 2021Review
- Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates.GeroScience · 2021Article
- Elder Mice Exhibit More Severe Degeneration and Milder Regeneration in Temporomandibular Joints Subjected to Bilateral Anterior Crossbite.Frontiers in physiology · 2021Article
- Bone phenotypes in rheumatology - there is more to bone than just bone.BMC musculoskeletal disorders · 2020Review
- Molecular Basis of Bone Aging.International journal of molecular sciences · 2020Review
- Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Ageing in the musculoskeletal system.Acta orthopaedica · 2016Review
- In vitro effects of 0 to 120 Grays of irradiation on bone viability and release of growth factors.BMC oral health · 2016Article
- Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Inhibitory effects of osteoprotegerin on osteoclast formation and function under serum-free conditions.Journal of veterinary science · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.
introductionOsteoclasts resorb aging bone in order to repair damage and maintain the quality of bone. The mechanism behind the targeting of aged bone for remodeling is not clear. We investigated whether bones endogenously possess the ability to control osteoclastic resorption.
methodsTo biochemically distinguish aged and young bones; we measured the ratio between the age-isomerized betaCTX fragment and the non-isomerized alphaCTX fragment. By measurement of TRACP activity, CTX release, number of TRACP positive cells and pit area/pit number, we evaluated osteoclastogenesis as well as osteoclast resorption on aged and young bones.
resultsWe found that the alphaCTX/betaCTX ratio is 3:1 in young compared to aged bones, and we found that both alpha and betaCTX are released by osteoclasts during resorption. Osteoclastogenesis was augmented on aged compared to young bones, and the difference was enhanced under low serum conditions. We found that mature osteoclasts resorb more on aged than on young bone, despite unchanged adhesion and morphology.
conclusionsThese data indicate that the age of the bone plays an important role in controlling osteoclast-mediated resorption, with significantly higher levels of osteoclast differentiation and resorption on aged bones when compared to young bones.
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Registered trials
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