ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2007
Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Exploring the impact of IL-2 cytokine family on skin barrier function: pathophysiology and therapeutic strategies.Molecular biology reports · 2026Review
- TLR2-Dependent Signaling for IL-15 Production Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes.Mediators of inflammation · 2016Article
- Disturbance of intraepithelial lymphocytes in a murine model of acute intestinal ischemia/reperfusion.Journal of molecular histology · 2014Article
- Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition.The Journal of physiology · 2013Article
- Article
- Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo.International journal of clinical and experimental pathology · 2012Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- Enteral versus parenteral nutrition: effect on intestinal barrier function.Annals of the New York Academy of Sciences · 2009Article
- Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration.Annals of surgery · 2008Article
- Specific overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Total parenteral nutrition (TPN), with the absence of enteral nutrition, results in profound changes to both intestinal epithelial cells (EC) as well as the adjacent intraepithelial lymphocyte (IEL) population. Intestinal EC are a rich source of IL-7, a critical factor to support the maintenance of several lymphoid tissues, and TPN results in marked EC changes. On this basis, we hypothesized that TPN would diminish EC-derived IL-7 expression and that this would contribute to the observed changes in the IEL population. Mice received enteral food and intravenous crystalloid solution (control group) or TPN. TPN administration significantly decreased EC-derived IL-7 expression, along with significant changes in IEL phenotype; decreased IEL proliferation; and resulted in a marked decrease in IEL numbers. To better determine the relevance of TPN-related changes in IL-7, TPN mice supplemented with exogenous IL-7 or mice allowed ad libitum feeding and treated with exogenous administration of anti-IL-7 receptor (IL-7R) antibody were also studied. Exogenous IL-7 administration in TPN mice significantly attenuated TPN-associated IEL changes, whereas blocking IL-7R in normal mice resulted in several similar changes in IEL to those observed with TPN. These findings suggest that a decrease in EC-derived IL-7 expression may be a contributing mechanism to account for the observed TPN-associated IEL changes.
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Registered trials
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