ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field.Pflugers Archiv : European journal of physiology · 2025Article
- Functional specificity of liquid-liquid phase separation at the synapse.Nature communications · 2024Article
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- Spontaneously Recycling Synaptic Vesicles Constitute Readily Releasable Vesicles in Intact Neuromuscular Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Physiological Perspectives on Molecular Mechanisms and Regulation of Vesicular Glutamate Transport: Lessons From Calyx of Held Synapses.Frontiers in cellular neuroscience · 2021Review
- Release Mode Dynamically Regulates the RRP Refilling Mechanism at Individual Hippocampal Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses.eLife · 2020Article
- Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses.iScience · 2020Article
- A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure.Frontiers in cellular neuroscience · 2020Article
- Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression.Translational psychiatry · 2016Article
- Presynaptic Molecular Determinants of Quantal Size.Frontiers in synaptic neuroscience · 2016Review
- Ultrastructural and functional fate of recycled vesicles in hippocampal synapses.Nature communications · 2015Article
- Strain Differences in Presynaptic Function: PROTEOMICS, ULTRASTRUCTURE, AND PHYSIOLOGY OF HIPPOCAMPAL SYNAPSES IN DBA/2J AND C57Bl/6J MICE.The Journal of biological chemistry · 2015Article
- Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A three-pool model dissecting readily releasable pool replenishment at the calyx of held.Scientific reports · 2015Article
- Monitoring of vacuolar-type H+ ATPase-mediated proton influx into synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Visualizing presynaptic function.Nature neuroscience · 2014Review
- Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.The Journal of biological chemistry · 2013Article
- Multiple dileucine-like motifs direct VGLUT1 trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
During short-term synaptic depression, neurotransmission rapidly decreases in response to repetitive action potential firing. Here, by blocking the vacuolar ATPase, alkalinizing the extracellular pH, or exposing hippocampal slices to pH buffers, we impaired neurotransmitter refilling, and electrophysiologically tested the role of vesicle reuse in synaptic depression. Under all conditions, synapses onto hippocampal CA1 pyramidal cells showed faster depression with increasing stimulation frequencies. At 20 Hz, compromising neurotransmitter refilling increased depression within 300 ms reaching completion within 2 s, suggesting a minimal contribution of reserve vesicles to neurotransmission. In contrast, at 1 Hz, depression emerged gradually and became significant within 100 s. Moreover, the depression induced by pH buffers was reversible with a similar frequency dependence, suggesting that the frequency-dependent increase in depression was caused by impairment of rapid synaptic vesicle reuse. These results indicate that synaptic vesicle trafficking impacts the kinetics of short-term synaptic plasticity at an extremely rapid time scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.