ArticleProceedings of the National Academy of Sciences of the United States of America2007
Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 99 citations in OpenAlex.
- Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.Scientific reports · 2016Trial
- Neuroimmunoendocrinology of SARS-CoV 2 Infection.Biomedicines · 2022Review
- The S100A7 nuclear interactors in autoimmune diseases: a coevolutionary study in mammals.Immunogenetics · 2022Article
- Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy.Frontiers in pediatrics · 2021Review
- Lessons from primary immunodeficiencies: Autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Immunological reviews · 2019Review
- The Hypothalamic-Pituitary Axis and Autoantibody Related Disorders.International journal of molecular sciences · 2017Review
- Article
- Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).Antibodies (Basel, Switzerland) · 2017Review
- Pituitary Microsomal Autoantibodies in Patients with Childhood-Onset Combined Pituitary Hormone Deficiency: an Antigen Identification Attempt.Archivum immunologiae et therapiae experimentalis · 2016Article
- Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects.Pituitary · 2016Review
- [Hypophysitis : Types and differential diagnosis].Der Pathologe · 2016Review
- Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.Journal of clinical immunology · 2015Review
- Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury.Journal of clinical medicine · 2015Review
- Hypoparathyroidism and central diabetes insipidus: in search of the link.European journal of pediatrics · 2014Article
- Article
- Anterior pituitary autoantibodies in patients with type 1 diabetes mellitus: methodological problems and clinical correlations.Journal of endocrinological investigation · 2014Article
- A history of pituitary pathology.Endocrine pathology · 2014Article
- Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis.Pituitary · 2014Article
- Antiadenohypophysis autoantibodies in patients with nongluten-related gastroenteropathies.Journal of clinical laboratory analysis · 2014Article
- Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays.European journal of endocrinology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies (Aabs) toward intracellular enzymes are a hallmark for APS1 and serve as diagnostic markers and predictors for disease manifestations. In this study, we aimed to identify pituitary autoantigens in patients with APS1. A pituitary cDNA expression library was screened with APS1 sera and a tudor domain containing protein 6 (TDRD6) cDNA clone was isolated. Positive immunoreactivity against in vitro translated TDRD6 fragments was shown in 42/86 (49%) APS1 patients but not in patients with other autoimmune diseases or in healthy controls. By using immunohistochemistry, sera from 3/6 APS1 patients with growth hormone (GH) deficiency showed immunostaining of a small number of guinea pig anterior pituitary cells, and 40-50% of these cells were GH-positive. No such immunostaining was seen with sera from healthy controls. The APS1 Aab-positive, GH-negative cells may represent a novel subpopulation of anterior pituitary cells. In addition, 4/6 patient sera showed staining of a fiber-plexus in the pituitary intermediate lobe recognizing enzymes of monoamine and GABA synthesis. Thus, we have identified TDRD6 as a major autoantigen in APS1 patients and shown that several sera from GH-deficient patients stain specific cell populations and nerves in the pituitary gland.
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