ArticleProceedings of the National Academy of Sciences of the United States of America2007
Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans.Development (Cambridge, England) · 2025Article
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Nibbling 405 kb off the X: Viable deletion alleles eliminating 50 protein coding genes, including a chromatin factor involved in neuronal development.microPublication biology · 2019Article
- Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality inGenetics · 2018Article
- Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit.PloS one · 2011Article
- MBT domain proteins in development and disease.Seminars in cell & developmental biology · 2010Review
- MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.Development (Cambridge, England) · 2009Article
- Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms underlying the formation of neurons with defined neurotransmitters are not well understood. In this study, we demonstrate that the PcG-like genes in Caenorhabditis elegans, sop-2 and sor-3, regulate the formation of dopaminergic and serotonergic neurons and several other neuronal properties. sor-3 encodes a novel protein containing an MBT repeat, a domain that contains histone-binding activity and is present in PcG proteins SCM and Sfmbt in other organisms. We further show that mutations in sor-3 lead to ectopic expression of Hox genes and cause homeotic transformations. Specification of certain neuronal identities by these PcG-like genes appears to involve regulation of non-Hox gene targets. Our studies revealed that the PcG-like genes are crucial for coordinately regulating the expression of discrete aspects of neuronal identities in C. elegans.
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