ArticleProceedings of the National Academy of Sciences of the United States of America2007
Neutron scattering reveals extremely slow cell water in a Dead Sea organism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 106 citations in OpenAlex.
- Quasi-elastic neutron scattering studies on bacterial spores and their hydration water.Scientific reports · 2026Article
- Determination ofJournal of the Royal Society, Interface · 2025Article
- Probing the structure of water in individual living cells.Nature communications · 2024Article
- Slow water dynamics in dehydrated human Jurkat T cells evaluated by dielectric spectroscopy with the Bruggeman-Hanai equation.RSC advances · 2023Article
- Exploring the Limits of Biological Complexity Amenable to Studies by Incoherent Neutron Spectroscopy.Life (Basel, Switzerland) · 2022Review
- Increase in the Intracellular Bulk Water Content in the Early Phase of Cell Death of Keratinocytes, Corneoptosis, as Revealed by 65 GHz Near-Field CMOS Dielectric Sensor.Molecules (Basel, Switzerland) · 2022Article
- Role of intracellular water in the normal-to-cancer transition in human cells-insights from quasi-elastic neutron scattering.Structural dynamics (Melville, N.Y.) · 2020Article
- Anomalous sub-diffusion of water in biosystems: From hydrated protein powders to concentrated protein solution to living cells.Structural dynamics (Melville, N.Y.) · 2020Article
- Article
- A New Look into the Mode of Action of Metal-Based Anticancer Drugs.Molecules (Basel, Switzerland) · 2020Article
- Water in protein hydration and ligand recognition.Journal of molecular recognition : JMR · 2019Review
- In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure.Scientific reports · 2019Article
- A Biophysical Perspective on Enzyme Catalysis.Biochemistry · 2019Article
- Water Dynamics in the Hydration Shells of Biomolecules.Chemical reviews · 2017Review
- The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering.Scientific reports · 2016Article
- High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes.Scientific reports · 2016Article
- Water Determines the Structure and Dynamics of Proteins.Chemical reviews · 2016Review
- Molecular adaptation and salt stress response of Halobacterium salinarum cells revealed by neutron spectroscopy.Extremophiles : life under extreme conditions · 2015Article
- Potassium stress growth characteristics and energetics in the haloarchaeon Haloarcula marismortui.Extremophiles : life under extreme conditions · 2015Article
- Specific and non-specific protein association in solution: computation of solvent effects and prediction of first-encounter modes for efficient configurational bias Monte Carlo simulations.The journal of physical chemistry. B · 2013Article
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11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular water dynamics in Haloarcula marismortui, an extremely halophilic organism originally isolated from the Dead Sea, was studied by neutron scattering. The water in centrifuged cell pellets was examined by means of two spectrometers, IN6 and IN16, sensitive to motions with time scales of 10 ps and 1 ns, respectively. From IN6 data, a translational diffusion constant of 1.3 x 10(-5) cm(2) s(-1) was determined at 285 K. This value is close to that found previously for other cells and close to that for bulk water, as well as that of the water in the 3.5 M NaCl solution bathing the cells. A very slow water component was discovered from the IN16 data. At 285 K the water-protons of this component displays a residence time of 411 ps (compared with a few ps in bulk water). At 300 K, the residence time dropped to 243 ps and was associated with a translational diffusion of 9.3 x 10(-8) cm(2) s(-1), or 250 times lower than that of bulk water. This slow water accounts for approximately 76% of cell water in H. marismortui. No such water was found in Escherichia coli measured on BSS, a neutron spectrometer with properties similar to those of IN16. It is hypothesized that the slow mobility of a large part of H. marismortui cell water indicates a specific water structure responsible for the large amounts of K(+) bound within these extremophile cells.
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