ArticleClinical and vaccine immunology : CVI2007
Use of mycelial-phase Sporothrix schenckii exoantigens in an enzyme-linked immunosorbent assay for diagnosis of sporotrichosis by antibody detection.
Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- The Historical Burden of Sporotrichosis in Brazil: a Systematic Review of Cases Reported from 1907 to 2020.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Pooled it
- Cutaneous disseminated sporotrichosis in an immunocompetent farmer.Medical mycology case reports · 2024Article
- Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil.Journal of fungi (Basel, Switzerland) · 2023Article
- Evaluation of Five Non-Culture-Based Methods for the Diagnosis of Meningeal Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2023Article
- Article
- Immunologic Diagnosis of Endemic Mycoses.Journal of fungi (Basel, Switzerland) · 2022Review
- Trends in Molecular Diagnostics and Genotyping Tools Applied for EmergingJournal of fungi (Basel, Switzerland) · 2022Review
- Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets.Pathogens (Basel, Switzerland) · 2022Review
- Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Promising application of the SsCBF ELISA test to monitor the therapeutic response of feline sporotrichosis caused by Sporothrix brasiliensis from Brazilian epidemics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Seroepidemiological survey on sporotrichosis-infection in rural areas of the south of Minas Gerais State, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Sporotrichosis In Immunocompromised Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Effects of metaperiodate and urea solutions on the serological diagnosis of human sporotrichosis using an indirect ELISA test.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Molecular Components of the Sporothrix schenckii Complex that Induce Immune Response.Current microbiology · 2016Review
- Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward Discovery of Potential Diagnostic and Vaccine Antigens.PLoS neglected tropical diseases · 2015Article
- Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis.Virulence · 2015Article
- Cross-reactivity in the Histoplasma antigen enzyme immunoassay caused by sporotrichosis.Clinical and vaccine immunology : CVI · 2011Article
- Sporothrix schenckii and Sporotrichosis.Clinical microbiology reviews · 2011Review
- Sporothrix schenckii Cell Wall Peptidorhamnomannans.Frontiers in microbiology · 2011Article
- Ribosomal DNA sequencing and phylogenetic analysis of environmental Sporothrix schenckii Strains: comparison with clinical isolates.Mycopathologia · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
An enzyme-linked immunosorbent assay (ELISA) was developed for specific antibody detection in serum specimens of patients with sporotrichosis. The assay was made with mycelial-phase Sporothrix schenckii exoantigens and was tested against 90 sera from patients with different clinical forms of sporotrichosis. Potential cross-reactions were analyzed with 72 heterologous sera from patients with paracoccidioidomycosis, cryptococcosis, aspergillosis, histoplasmosis, tuberculosis, and American tegumentary leishmaniasis, as well as 76 sera from healthy controls. We found a sensitivity of 97% and a specificity of 89% in this assay. Some cross-reactions were seen, as observed in other immunoassays for the diagnosis of sporotrichosis. The ELISA appears to be especially useful for cutaneous forms of disease, since these are not promptly diagnosed with available immunoprecipitation or agglutination techniques. These results suggest that the ELISA using mycelial-phase S. schenckii exoantigens is a very sensitive diagnostic tool for the serodiagnosis of sporotrichosis and can be used in conjunction with conventional methods of diagnosis, particularly in cases where cross-reactions or false-positive results are experienced with the serodiagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.