ArticleSexually transmitted infections2006
Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis.
Article in Sexually transmitted infections, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis.Sexually transmitted infections · 2017Pooled it
- Optimizing Peer Distribution of Syphilis Self-Testing Among Men Who Have Sex with Men in China: A Multi-City Pragmatic Randomized Controlled Trial.Archives of sexual behavior · 2023Trial
- Clinic-based evaluation of point-of-care dual HIV/syphilis rapid diagnostic tests at primary healthcare antenatal facilities in South Africa and Zambia.BMC infectious diseases · 2024Article
- Article
- Lifetime prevalence of syphilis infection among predominantly Black sexual and gender minorities living with HIV in Atlanta, Georgia: a cross-sectional analysis.Ethnicity & health · 2023Article
- Psoriasiform syphilis: A challenge.Dermatology reports · 2021Article
- Social network distribution of syphilis self-testing among men who have sex with men in China: study protocol for a cluster randomized control trial.BMC infectious diseases · 2021Article
- Laboratory assessment of SD Bioline HIV/Syphilis Duo Kit among pregnant women attending antenatal clinic Mayuge Health Center III, East central Uganda.BMC research notes · 2019Article
- Field performance evaluation of dual rapid HIV and syphilis tests in three antenatal care clinics in Zambia.International journal of STD & AIDS · 2019Article
- Laboratory Evaluation of a Commercially Available Rapid Syphilis Test.Journal of clinical microbiology · 2018Article
- Evaluation of the utility of a rapid test for syphilis at a sexually transmitted disease clinic in Buenos Aires, Argentina.Scientific reports · 2018Article
- Field evaluation of SD BIOLINE HIV/Syphilis Duo assay among pregnant women attending routine antenatal care in Juba, South Sudan.PloS one · 2018Article
- Syphilis.Nature reviews. Disease primers · 2017Review
- The introduction of syphilis point of care tests in resource limited settings.Expert review of molecular diagnostics · 2017Review
- Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis.Sexually transmitted diseases · 2016Article
- Evaluation of the diagnostic performance and operational characteristics of four rapid immunochromatographic syphilis tests in Burkina Faso.African health sciences · 2015Article
- Assessment of the impact of rapid syphilis tests on syphilis screening and treatment of pregnant women in Zambia.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015Article
- Article
- Article
- Point of care diagnostics for sexually transmitted infections: perspectives and advances.Expert review of anti-infective therapy · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 7 countries.
Funding
Abstract
objectivesTo evaluate prospectively four rapid, point-of-care serological tests for syphilis in prenatal or high risk populations in four countries.
methodsTests were performed on consecutive clinic attenders, using whole blood in the clinic, and whole blood and serum in the laboratory. The sensitivity and specificity of each test was evaluated, using a standard treponemal test (Treponema pallidum haemagglutination assay (TPHA) or fluorescent treponemal antibody, absorbed (FTA-ABS) as gold standard. Non-treponemal tests (rapid plasma reagin (RPR) or venereal diseases research laboratory (VDRL) tests) were also performed on all subjects at three sites.
resultsThe specificity of each rapid test was >95% at each site. Sensitivities varied from 64-100% and, in most cases, were lower when whole blood was used rather than serum.
conclusionsRapid serological tests for syphilis are an acceptable alternative to conventional laboratory tests. Since they do not require equipment or electricity, they could increase coverage of syphilis screening, and enable treatment to be given at the first clinic visit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.