ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2007
Temporal changes in gene expression in rainbow trout exposed to ethynyl estradiol.
Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Interactive effects of dietary lipid and phenotypic feed efficiency on the expression of nuclear and mitochondrial genes involved in the mitochondrial electron transport chain in rainbow trout.International journal of molecular sciences · 2015Article
- Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.BMC genomics · 2014Article
- The role of biomarkers in the assessment of aquatic ecosystem health.Integrated environmental assessment and management · 2014Review
- Aquatic animal models of human disease: selected papers and recommendations from the 4th Conference.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2009Article
- Construction of a robust microarray from a non-model species (largemouth bass) using pyrosequencing technology.Journal of fish biology · 2008Article
- Discovery of genes implicated in whirling disease infection and resistance in rainbow trout using genome-wide expression profiling.BMC genomics · 2008Article
- Aquatic animal models of human disease.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We examined changes in the genomic response during continuous exposure to the xenoestrogen ethynyl estradiol. Isogenic rainbow trout Oncorhynchus mykiss were exposed to nominal concentrations of 100 ng/L ethynyl estradiol (EE2) for a period of 3 weeks. At fixed time points within the exposure, fish were euthanized, livers harvested and RNA extracted. Fluorescently labeled cDNA were generated and hybridized against a commercially available Salmonid array (GRASP project, University of Victoria, Canada) spotted with 16,000 cDNAs. The slides were scanned to measure abundance of a given transcript in each sample relative to controls. Data were analyzed via Genespring (Silicon Genetics) to identify a list of up and down regulated genes, and to determine gene clustering patterns that can be used as "expression signatures". Gene ontology was determined using the annotation available from the GRASP website. Our analysis indicates each exposure time period generated specific gene expression profiles. Changes in gene expression were best understood by grouping genes by their gene expression profiles rather than examining fold change at a particular time point. Many of the genes commonly used as biomarkers of exposure to xenoestrogens were not induced initially and did not have gene expression profiles typical of the majority of genes with altered expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.