Evidence map›Paper›PMID 1721489›Full record

ArticleThe American journal of pathology1991

L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.

C Schmid, C Sargent, P G Isaacson

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In one paragraph

Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 86 citations in OpenAlex.

  1. Trial
  2. Review
  3. Flow Cytometry for Non-Hodgkin and Hodgkin Lymphomas.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C SchmidDepartment of Histopathology, University College and Middlesex School of Medicine, London, United Kingdom.
C Sargent
P G Isaacson
Middlesex University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nodular form of lymphocyte predominant Hodgkin's disease (NLPHD) is widely accepted to be a B-cell-derived neoplasm. Despite this consensus, previous studies have not shown monotypic immunoglobulin (Ig) light-chain expression by the putatively malignant L & H cells. We have studied paraffin-embedded tissue from 19 cases of NLPHD for the presence of Ig light and heavy chains and J chain. In addition, frozen tissue, available from one case, was examined with antibodies to light chains. In paraffin material, in each case L & H cells in individual nodules were examined for the presence of Ig light chain restriction. Kappa-light-chain restriction was detected in all L & H cells in all nodules in 5/19 cases (26.5%) and this was confirmed in frozen sections available from one case. Of the remaining 14 cases, 13 (68.5%) showed kappa-light-chain restriction in a proportion of nodules and in 1 case light-chain restriction was not observed. Of 14 cases stained with antibodies to Ig heavy chains 13 contained IgG, and in 1 case no heavy chains were demonstrable. Most L & H cells in 15 cases examined contained J chain. Our finding of monotypic L & H cells in NLPHD in 95% of our investigated cases provides strong evidence for the neoplastic nature of L & H cells and supports the hypothesis that NLPHD is a malignant nonHodgkin's B-cell lymphoma.

Indexed as

Antigens, CDHodgkin DiseaseHumansImmunoglobulin GImmunoglobulin J-ChainsImmunoglobulin Light ChainsImmunohistochemistryLymphocytesStaining and LabelingAntigens, CDImmunoglobulin GImmunoglobulin J-ChainsImmunoglobulin Light Chains

Identifiers

PMID1721489
PMCPMC1886478
OpenAlexW1687670048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.