Trial reportMenopause (New York, N.Y.)
Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women.
Trial report in Menopause (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00668447 (Soy Proteins and Isoflavones Impact Bone Mineral Density in Older Women), which is not on this map. Cited by 38 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Soy Proteins and Isoflavones Impact Bone Mineral Density in Older Women
Who cites it
38 citing papers in PubMed, 15 syntheses or guidelines pooled it.
- Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Effect of Plant Versus Animal Protein on Muscle Mass, Strength, Physical Performance, and Sarcopenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Nutrition reviews · 2025Pooled it
- Effects of combined protein and exercise interventions on bone health in middle-aged and older adults - A systematic literature review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Effects of exercise on bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2025Pooled it
- The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Exercise training and bone mineral density in postmenopausal women: an updated systematic review and meta-analysis of intervention studies with emphasis on potential moderators.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2021Pooled it
- Effects of Different Types of Exercise on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-analysis.Calcified tissue international · 2020Pooled it
- Isoflavone combined with exercise on bone mineral density in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.Journal of the Chinese Medical Association : JCMA · 2020Pooled it
- Effect of Exercise Training on Bone Mineral Density in Post-menopausal Women: A Systematic Review and Meta-Analysis of Intervention Studies.Frontiers in physiology · 2020Pooled it
- Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Pooled it
- Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation.PloS one · 2018Pooled it
- Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling.Journal of medicinal food · 2016Pooled it
- Effects of training on bone mass in older adults: a systematic review.Sports medicine (Auckland, N.Z.) · 2012Pooled it
- Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis.Age (Dordrecht, Netherlands) · 2011Pooled it
- The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women.Journal of bone and mineral metabolism · 2014Trial
- Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Trial
- The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women.The American journal of clinical nutrition · 2010Trial
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD).
designThis study used a placebo-controlled, double-blind (soy), randomized 2 (SPI vs milk protein isolate [MPI]) x 2 (EX vs no EX) design. Sixty-one postmenopausal women were randomized, and 43 (62 +/- 5 y) completed the 9-month intervention (SPI, n = 10; MPI, n = 12; SPI + EX, n = 11; MPI + EX, n = 10). Serum C-terminal cross-linked telopeptides of type I collagen and serum bone-specific alkaline phosphatase were measured as markers of bone resorption and formation, respectively. BMD was measured by dual-energy x-ray absorptiometry.
resultsAt 9 months, SPI reduced serum C-terminal cross-linked telopeptides (-13.3% +/- 15.3% vs -1.5% +/- 21.0%; P = 0.02) and serum bone-specific alkaline phosphatase (-4.7% +/- 14.7% vs 6.5% +/- 17.7%; P = 0.02) compared to milk protein isolate. EX attenuated the reduction in serum C-terminal cross-linked telopeptides (-1.9% +/- 21.6% vs -12.4% +/- 15.3%; P = 0.04); however, no EX effects were apparent in serum bone-specific alkaline phosphatase at 9 months (2.8% +/- 16.1% vs -1.0% +/- 18.3%; P = 0.28). Neither SPI nor EX affected BMD at any site; however, change in BMD was related to change in fat mass (r = 0.40, P < 0.05).
conclusionsIn postmenopausal women (1) SPI reduces bone turnover with no impact on BMD over 9 months; (2) moderate-intensity endurance exercise training did not favorably alter bone turnover and had no impact on BMD; and (3) there were no additive effects of soy and exercise on bone turnover or BMD.
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