Trial reportJournal of pharmacokinetics and pharmacodynamics2007
Estimation of population pharmacokinetic parameters of saquinavir in HIV patients with the MONOLIX software.
Trial report in Journal of pharmacokinetics and pharmacodynamics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
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- Model-Based Approach to Predict Adherence to Protocol During Antiobesity Trials.Journal of clinical pharmacology · 2018Trial
- Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis.Antimicrobial agents and chemotherapy · 2017Trial
- Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.Journal of pharmacokinetics and pharmacodynamics · 2016Trial
- Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy.The Journal of antimicrobial chemotherapy · 2015Trial
- Population pharmacokinetics of single-dose amikacin in critically ill patients with suspected ventilator-associated pneumonia.European journal of clinical pharmacology · 2015Trial
- Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.British journal of clinical pharmacology · 2014Trial
- Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes.BMC pharmacology & toxicology · 2013Trial
- Influence of methotrexate on infliximab pharmacokinetics and pharmacodynamics in ankylosing spondylitis.British journal of clinical pharmacology · 2012Trial
- Population pharmacokinetics of ritonavir-boosted saquinavir regimens in HIV-infected individuals.The Journal of antimicrobial chemotherapy · 2008Trial
- A computational framework for optimizing radioiodine therapy protocols in metastatic thyroid cancer.Scientific reports · 2026Article
- Clinical trial simulation of antiviral drugs.Journal of virology · 2026Review
- Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab: Results From the VedoKids Prospective Multicentre Study.Alimentary pharmacology & therapeutics · 2025Article
- A Framework for Quantitative Systems Pharmacology Model Execution.Handbook of experimental pharmacology · 2025Review
- Model-informed drug discovery and development approaches to inform clinical trial design and regulatory decisions: A primer for the MENA region.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Review
- Influenza virus shedding and symptoms: Dynamics and implications from a multiseason household transmission study.PNAS nexus · 2024Article
- Public Health Impact of Paxlovid as Treatment for COVID-19, United States.Emerging infectious diseases · 2024Article
- Exploring carbon source related localization and phosphorylation in the Snf1/Mig1 network using population and single cell-based approaches.Microbial cell (Graz, Austria) · 2024Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
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Abstract
In nonlinear mixed-effects models, estimation methods based on a linearization of the likelihood are widely used although they have several methodological drawbacks. Kuhn and Lavielle (Comput. Statist. Data Anal. 49:1020-1038 (2005)) developed an estimation method which combines the SAEM (Stochastic Approximation EM) algorithm, with a MCMC (Markov Chain Monte Carlo) procedure for maximum likelihood estimation in nonlinear mixed-effects models without linearization. This method is implemented in the Matlab software MONOLIX which is available at http://www.math.u-psud.fr/~lavielle/monolix/logiciels. In this paper we apply MONOLIX to the analysis of the pharmacokinetics of saquinavir, a protease inhibitor, from concentrations measured after single dose administration in 100 HIV patients, some with advance disease. We also illustrate how to use MONOLIX to build the covariate model using the Bayesian Information Criterion. Saquinavir oral clearance (CL/F) was estimated to be 1.26 L/h and to increase with body mass index, the inter-patient variability for CL/F being 120%. Several methodological developments are ongoing to extend SAEM which is a very promising estimation method for population pharmacockinetic/pharmacodynamic analyses.
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